In vivo real time imaging of esophageal cancer with CdSe nanoparticle

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We developed ultra-stable nanoparticles of CdSe conjugated with anti-Her2 antibody as a novel functional fluorescent probe for in vivo imaging. After intravenous injection of this nanoparticle, we were able to detect the fluorescent signals and image of human esophageal cancer in tumor-bearing nude mouse from outside the body successfully. Furthermore, we developed new surgical system for endoscopic fluorescent surgery based on clinical application. Using this fluorescent detection system and CdSe as a nano-tracer, we succeeded in real time imaging of lymph networks and sentinel lymph node biopsy of gastrointestinal tract in pig model.