Utility of Real-time Virtual Sonography (RVS), anew breast imaging method for coordinating sonography with an MRIusing an image fusion technique

我们开发了实时虚拟超声(RVS)，这是一种使用图像融合技术将超声与MRI系统相结合的方法。自2005年以来，我们将这种方法应用于MRI检测到的乳腺病变的超声评估。我们之前曾报道，在2009年，98%的MRI增强指数肿块和83%的MRI检测到的病变是使用RVS识别的(Nakano等人)。Jpn J Clinic Oncol2009年)。本研究的目的是(1)评估RVS在乳腺MRI发现的强化病变的超声识别中的靶向准确性；(2)验证RVS在二次探头超声检查中的应用。(1)从三维角度分析了定位误差，即从实际超声位置到期望位置的距离。横断面和矢状面的平均定位误差分别为7.7 mm、6.9 mm和2.8 mm。总体平均三维定位误差为12.0 mm(Nakano等人)。BUSIC Med Biol 2012)。(2)分析常规B超和RVS二次探头检查的病变发现率之间的相关性。在67个病变(其中恶性24个，良性43个)中，常规B型超声的检出率为27%(18/67)，RVS的检出率明显升高至90%(60/67)(p&lt；0.001)(〓等人)。乳腺癌资源治疗2012年)。我们的结果表明，在超声图像与磁共振结果的直接比较中，RVS具有良好的靶向准确性，并且在二次超声信号〓中额外使用RVS可以在不依赖操作员的情况下提高MRI检测到的病变的超声诊断率。我们认为，RVS代表了一种很有前途的乳房成像新方式。

We have developed real-time virtual sonography (RVS), a method for coordinating sonography with an MRI system using an image fusion technique. Since 2005, we have applied this method to sonographic evaluation of MRI-detected lesions of the breast. We reported previously that in 2009, 98% of MRI enhanced index mass and 83% of MRI-detected lesions were identified using RVS (Nakano, et al. Jpn J Clinic Oncol 2009). The aims of this study were (1) to evaluate the targeting accuracy of RVS in sonographic identification of enhancing lesions detected by breast MRI, and (2) to verify the utility of second-look sonography using RVS. (1) We analyzed the positioning error, i.e., the distance from the actual sonographic position to the expected MRI position, in three dimensions. The meanpositioning errors for the transverse and sagittal planes and the depth from the skin were 7.7, 6.9, and 2.8 mm, respectively. The overall mean three-dimensional positioning error was 12.0 mm (Nakano, et al. Ultrasound Med Biol 2012). (2) We analyzed the correlations between lesion detection rates on second-look sonography using conventional B-mode or RVS. Among 67 lesions (24 malignant and 43 benign), the detection rate of conventional B-mode was 27% (18/67); RVS increased these rates signi〓cantly, to 90 % (60/67) (p <0.001) (Nakano, et al. Breast Cancer Res Treat 2012). Our results suggest that RVS has good targeting accuracy in a direct comparison of a sonographic image with MRI results, and the additional use of RVS on second-look sonography signi〓cantly increases the sonographic detection rate of MRI-detected lesions without operator dependence. Webelieve that RVS represents a promising new modality for breast imaging.