Real-time Tumor Localization and Guidance for Radiotherapy Using US and MRI

使用超声和 MRI 进行实时肿瘤定位和放射治疗指导

• 批准号: 9321769
• 负责人: Bryan Patrick Bednarz
• 金额: $ 63.23万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9321769
• 关键词: 4D MRI; Abdomen; Address; Algorithms; Anatomy; Area; Biopsy; Brachytherapy; Calibration; Cancer Patient; Cancer Survivor; Chest; Clinical; Clinical Trials; Coupled; Data; Dose; Drug Delivery Systems; Environment; Future; Goals; Hand; Image; Imagery; Individual; Linear Accelerator Radiotherapy Systems; Liver neoplasms; Location; Magnetic Resonance Imaging; Malignant neoplasm of liver; Measurement; Medical; Methods; Modality; Motion; Operative Surgical Procedures; Organ; Outcome; Patients; Phase; Physics; Play; Precision therapeutics; Procedures; Process; Radiation; Radiation Oncology; Radiation therapy; Reproducibility; Research; Research Personnel; Resolution; Resources; Roentgen Rays; Role; Speed; Structure; System; Techniques; Technology; Therapeutic; Time; Tissues; Training; Tumor Volume; Ultrasonic Transducer; Ultrasonography; United States; Universities; Validation; Variant; Wisconsin; Work; base; cancer cell; cancer imaging; cancer therapy; cost; cost effective; design; image guided; image guided radiation therapy; image processing; imaging capabilities; imaging probe; improved; indexing; innovation; magnetic field; multidisciplinary; novel; operation; proton therapy; public health relevance; radiation absorbed dose; respiratory; signal processing; soft tissue; success; treatment planning; treatment strategy; tumor; virtual

 DESCRIPTION (provided by applicant): By 2020, the expected number of cancer survivors in the US is projected to rise to 18.1 million individuals costing an estimated $158 billion US dollars. Radiation therapy currently plays an essential role in the management of nearly 60% of all cancer treatments. The success of radiotherapy depends on the ability to target malignant cells with radiation while simultaneously protecting surrounding healthy tissue from damaging effects. This is often challenged by respiratory-induced motion in the thoracic and abdominal regions during the delivery of the treatment. Our proposal addresses the current need for a cost-effective and non-invasive real- time motion management platform for radiotherapy that does not increase the dose burden to patients. We will develop and validate a novel image-guidance technique to directly track tumor motion using a 4D planar ultrasound transducer during radiation therapy that is coupled to a pre-treatment calibration training image set consisting of a simultaneous 4D ultrasound and 4D MRI acquisition. The image sets will be rapidly matched using advanced image and signal processing algorithms, allowing the display of virtual MR images of the tumor/organ motion in real-time from an ultrasound acquisition. Although our proposal focuses on radiation therapy of liver cancers, it is applicable to other areas of the body A multi-disciplinary team of researchers from University of Wisconsin (UW) and General Electric Global Research Center (GRC) covering expertise in ultrasound imaging and probe design, MRI, signal processing, radiation therapy physics and treatment planning. The completion of this work will result in several innovations including: a (2D) patch-like, MR and LINAC compatible 4D planar ultrasound transducer that is electronically steerable for hands-free operation to provide real-time virtual MR and ultrasound imaging for motion management during radiation therapy; a multi- modal tumor localization strategy that uses US and MRI; fast and accurate image processing algorithms that provide real-time information about the motion and location of tumor related soft-tissue structures within the patient; and, a novel image-guided radiation therapy motion management platform that will be used to guide treatments based on direct visualization of the moving tumor. The broad, long-term objective of this research is to demonstrate that our platform leads to improved clinical outcome in cancer patients by significantly increasing the therapeutic ratio between a moving tumor target volume and relevant sensitive structures Furthermore, the application of our proposal is not limited to IGRT, as the technology may be applied to other image-guided procedures (proton therapy, brachytherapy, biopsies, surgery, and drug delivery).

 描述（由适用提供）：到2020年，美国预期的癌症存活率预计将增加到1,810万个人，估计耗资约1,580亿美元。目前，放射治疗在几乎60％的所有癌症治疗中都起着至关重要的作用。放射疗法的成功取决于用辐射靶向恶性细胞的能力，同时保护健康组织免受破坏性影响。这通常受到治疗输送过程中胸腔和腹部区域呼吸引起的运动的挑战。我们的提案解决了目前对放射疗法的经济高效和非侵入性实时运动管理平台的需求，该平台不会增加对患者的剂量燃烧。我们将在放射治疗期间使用4D平面超声传感器直接跟踪肿瘤运动并验证一种新型的图像引导技术，该技术在放射治疗过程中与预处理预校准训练训练图像集耦合，该图像集由A组成 同时进行4D超声波和4D MRI采集。图像集将使用高级图像和信号处理算法迅速匹配，从而可以通过超声采集实时显示肿瘤/器官运动的虚拟MR图像。尽管我们的建议着重于肝癌的放射疗法，但它适用于人体其他领域，由威斯康星大学（UW）（UW）和通用电气全球研究中心（GRC）组成的多学科研究团队，涵盖了超声成像和探针设计方面的专业知识，MRI，信号处理，放射治疗，放射治疗物理学和治疗计划。这项工作的完成将导致几项创新，包括：（2D）贴片，MR和Linac兼容4D平面超声传感器，在电子上可以轻松操作以免费手提操作可为放射治疗期间提供实时的虚拟MR和超声成像；使用我们和MRI的多模式肿瘤定位策略；快速准确的图像处理算法，提供有关患者内部肿瘤相关软组织结构运动和位置的实时信息；以及一个新型的图像引导辐射疗法运动管理平台，该平台将用于基于移动肿瘤的直接可视化来指导治疗。 The broad, long-term objective of this research is to demonstrate that our platform leads to improved clinical outcome in cancer patients by significantly increasing the therapeutic ratio between a moving tumor target volume and relevant sensitive structures Furthermore, the application of our proposal is not limited to IGRT, as the technology may be applied to other image-guided procedures (proton therapy, brachytherapy, biopsies, surgery, and drug delivery).