The possibility of hepatic regenerative medicine usingadipose tissue-derived mesenchymal stem cell (ADRC)

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Adipose tissue represents an abundant source of adult stem cells, termed ‘adipose-derived regenerative cells (ADRC)’, with the ability to differentiate along multiple lineage pathways. In this study, we demonstrated that ADRCs could be differentiated into hepatocyte like cells, as well as protected hepatocytes by a trophic effectand a homing effect through CXCR4 / SDF1 axis in vitro and in vivo 70% hepatectomy following ischemia reperfusion rat model.