The possibility of artificial myocardial assist system to support failed heart model.

人工心肌辅助系统支持衰竭心脏模型的可能性。

• 批准号: 22591534
• 负责人: AKIYAMA Masatoshi
• 金额: $ 2.5万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591534/
• 关键词: 心不全; 僧帽弁閉鎖不全; 低侵襲手術; 人工心筋; 心臓外科; 循環器・高血圧; 補助循環

According to the results of our previous study, which was the hemodynamic support by artificial myocardium to the normal heart, the artificial myocardium was applied to the canine heart failure model induced by rapid ventricular pacing. However, its effect was not enough to improve hemodynamic parameters. The cause was suspected that the geometry of normal heart and failed heart was different. The wrapping pattern of artificial myocardium was studied using Mock circulation with the spherical sack, and the ideal pattern for failed heart was confirmed. We performed acute study using canine heart failure model again. The hemodynamic data was collected using the conductance catheter and echocardiography. The artificial myocardium led the increase of Emax value and the decrease of functional mitral regurgitation volume. These results support that the artificial myocardium could be the alternative therapy of advanced heart failure. In future, chronic evaluation of artificial myocardium is necessary for its effectiveness, durability, and safety.

根据我们前期人工心肌对正常心脏血流动力学支持的研究结果，将人工心肌应用于快速心室起搏诱导的犬心力衰竭模型。但其效果不足以改善血流动力学参数。其原因可能与正常心脏和衰竭心脏的几何形状不同有关。采用球形囊袋模拟循环，对人工心肌的包裹方式进行了研究，确定了衰竭心脏理想的包裹方式。再次采用犬心衰模型进行急性期研究。采用电导导管和超声心动图采集血流动力学数据。人工心肌使Emax值增加，功能性二尖瓣反流量减少。这些结果支持人工心肌可能成为晚期心力衰竭的替代治疗方法。为了保证人工心肌的有效性、耐久性和安全性，需要对人工心肌进行长期评价。

项目成果

First Analysis Of Artificial Myocardium Applied To Chronic Heart Failure In Canine Model

人工心肌应用于犬慢性心力衰竭模型的首次分析

• 发表时间: 2013
• 作者: Yukihiro Hayatsu;Masatoshi Akiyama;Yasuyuki Shiraishi;Akihiro Yamada;Kazumasu Sasaki;Shunsuke Kawamoto,Tomoyuki Yambe;Yoshikatsu Saiki
• 通讯作者: Yoshikatsu Saiki

本間大極細形状記憶合金線維の多層化による人工心筋システムの改良

通过多层本间超细形状记忆合金纤维改善人工心肌系统

• 发表时间: 2012
• 作者: 深原一晃;土居寿男;山下重幸;湖東慶樹;三崎拓郎;白石泰之,山田昭博,Mohamed Hashem Omran,坪子侑佑,三浦英和,西條芳文,山家智之,秋山正年,早津幸弘,齋木佳克
• 通讯作者: 白石泰之,山田昭博,Mohamed Hashem Omran,坪子侑佑,三浦英和,西條芳文,山家智之,秋山正年,早津幸弘,齋木佳克