The possibility of artificial myocardial assist system to support failed heart model.

根据我们前期人工心肌对正常心脏血流动力学支持的研究结果，将人工心肌应用于快速心室起搏诱导的犬心力衰竭模型。但其效果不足以改善血流动力学参数。其原因可能与正常心脏和衰竭心脏的几何形状不同有关。采用球形囊袋模拟循环，研究了人工心肌的包裹方式，确定了衰竭心脏理想的包裹方式。再次采用犬心衰模型进行急性期研究。采用电导导管和超声心动图采集血流动力学数据。人工心肌使Emax值增加，功能性二尖瓣反流量减少。这些结果支持人工心肌可能成为晚期心力衰竭的替代治疗方法。为了保证人工心肌的有效性、耐久性和安全性，需要对人工心肌进行长期评价。

According to the results of our previous study, which was the hemodynamic support by artificial myocardium to the normal heart, the artificial myocardium was applied to the canine heart failure model induced by rapid ventricular pacing. However, its effect was not enough to improve hemodynamic parameters. The cause was suspected that the geometry of normal heart and failed heart was different. The wrapping pattern of artificial myocardium was studied using Mock circulation with the spherical sack, and the ideal pattern for failed heart was confirmed. We performed acute study using canine heart failure model again. The hemodynamic data was collected using the conductance catheter and echocardiography. The artificial myocardium led the increase of Emax value and the decrease of functional mitral regurgitation volume. These results support that the artificial myocardium could be the alternative therapy of advanced heart failure. In future, chronic evaluation of artificial myocardium is necessary for its effectiveness, durability, and safety.