Analyzing corticobasal network with deep brain stimulation and diffsion tensor imaging

我们已经建立了一种新的功能分析方法，通过整合解剖和电生理信息，从扩散张量成像，纤维束成像，并在晚期帕金森病患者的脑深部电刺激。我们清楚地显示了在脑深部电刺激患者中锥体、锥体外系、脊髓丘脑和丘脑皮质网络的纤维束。通过映射电刺激对纤维束成像和弥散张量成像数据的影响，我们生成了每种情况下的功能神经解剖图谱。此外，还分析了脑深部电刺激对晚期帕金森病的纤维束成像图、睡眠神经网络和精神症状的非运动效应。

We have established a novel functional analyzing method by integrating anatomical and electrophysiological information from diffusion tensor imaging, fiber tractography, and deep brain stimulation in patients with advanced Parkinson’s disease. We clearly demonstrated the fiber tracts for pyramidal, extrapyramidal, spinothalamic, and thalamocortical netoworks in patients with deep brain stimulation. By mapping the electrical stimulation effects on the fiber tractgraphy and diffusion tensor imaging data, we generated functional neuroanatomical atlases were in each case. Also non-motor effects of deep brain stimulation were analyzed on the map of tractography, neuronal networks involved in sleep and psychiatric symptoms in advanced Parkinson’s disease.