Impact of pain on the learning and memory - Behavioral assessment and histological and physiological study in the central nervous system -

疼痛对学习和记忆的影响 - 中枢神经系统的行为评估和组织学和生理学研究 -

• 批准号: 22591744
• 负责人: OGAWA Ken-ichi
• 金额: $ 2.83万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591744/
• 关键词: 術後疼痛; 記憶学習; 海馬; 急性痛; 忌避刺激; 電気生理学; 疼痛; 海馬・扁桃体; 術後鎮痛

The aim of this study is to clarify the impact of pain and its analgesia on memory and learning. We investigated the effects of acute postoperative pain on fear stimulus memories, one trial passive avoidance learning test was performed using a rat simple laparotomy model. We performed IA-conditioning to the rats 2 hours after the surgery and we conducted IA-test to 24 hours after surgery. Contrary to the expectations, latency to the entering black box had not changed in both groups. Furthermore, we compared the amount of GluA1 subunit of AMPA receptor, which is known to be involved in learning and memory in the hippocampus, in hippocampus synaptosome 24 hours after surgery and there was no difference between laparotomy group and control group. The results of this study suggested that postoperative acute pain may not directly affect the learning and memory disorders of perioperative period.

本研究的目的是阐明疼痛及其镇痛对记忆和学习的影响。本研究采用大鼠单纯剖腹手术模型，通过一次性被动回避学习实验，探讨了术后急性疼痛对恐惧刺激记忆的影响。术后2h对大鼠进行IA预处理，术后24h进行IA试验。与预期相反，进入黑盒的延迟在两组中都没有改变。此外，我们比较了手术后24小时海马突触体中已知参与海马学习和记忆的AMPA受体GluA 1亚基的含量，剖腹组和对照组之间没有差异。本研究结果表明，术后急性疼痛可能不会直接影响围手术期的学习记忆障碍。