Development of optimized hemodynamic therapy guided by mean circulatory filling pressure or stressed blood volume.

开发以平均循环充盈压或应激血容量为指导的优化血液动力学治疗。

• 批准号: 22591758
• 负责人: SHISHIDO Toshiaki
• 金额: $ 2.83万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591758/
• 关键词: 有効循環血液量; 循環系平均充満圧; 血行動態管理; 血行動態モデル; 周術期管理; 循環器; 輸液療法; 制御工学; 医療・福祉; 循環器病学; 心臓力学; 循環生理学

Although intravenous therapy is important in performing intensive care or perioperative management, its effectiveness depends greatly on the skill or experience of medical specialists. The present study examined the possibility of new hemodynamic optimization therapy guided by mean circulatory filling pressure or stressed blood volume in the comprehensive Guyton's cardiovascular model. It seemed that the stressed blood volume is suitable for this optimization therapy because the stressed blood volume has a wider dynamic range for hemodynamic change than the mean circulatory filling pressure. The patient feasibility study with acute heart failure suggested that either the mean circulatory filling pressure or the stressed blood volume may quantify the optimal timing to administer positive inotropes.

虽然静脉治疗在重症监护或围手术期管理中很重要，但其有效性在很大程度上取决于医学专家的技能或经验。本研究探讨了在综合盖顿心血管模型中，由平均循环充盈压或应激血容量指导的新的血流动力学优化治疗的可能性。应力血容量似乎适用于这种优化治疗，因为应力血容量比平均循环充盈压具有更宽的血流动力学变化动态范围。急性心力衰竭患者的可行性研究表明，平均循环充盈压或应激血容量可以量化给予正性肌力药物的最佳时机。

项目成果

Reduction of myocardial oxygen demand by controlling heart rate and hemodynamics simultaneously by novel circulatory model.

通过新型循环模型同时控制心率和血流动力学来减少心肌需氧量。

• 发表时间: 2011
• 作者: Sugimachi M;Uemura K;Kawada T;Shishido T;Sunagawa K.
• 通讯作者: Sunagawa K.

Serial changes in renal function as a prognostic indicator in advanced heart failure patients with left ventricular assist system.

• DOI: 10.1016/j.athoracsur.2011.11.058
• 发表时间: 2012-03
• 期刊: The Annals of thoracic surgery
• 作者: Y. Iwashima;M. Yanase;T. Horio;O. Seguchi;Y. Murata;T. Fujita;K. Toda;Y. Kawano;T. Nakatani

Physiological significance of pressure-volume relationship : A load-independent index and a determinant of pump function

压力-容积关系的生理意义：与负载无关的指数和泵功能的决定因素

• 发表时间: 2010
• 作者: Sugimachi M;Sunagawa K;Uemura K;Shishido T
• 通讯作者: Shishido T

左心補助人工心臓埋込み術前の心ポンプ機能評価から術後の強心剤離脱困難症例を予測できるか?

是否可以通过左心辅助装置植入前的心泵功能评估来预测手术后撤药困难的情况？

• 发表时间: 2010
• 作者: 村田欣洋;宍戸稔聡;中島育太郎;瀬口理;築瀬正伸;藤田知之;戸田宏一;上村和紀;杉町勝;中谷武嗣
• 通讯作者: 中谷武嗣

Preoperative right ventricular pump function predicts the feasibility of weaning from inotropic support after implantation of left ventricular assist system.

术前右心室泵功能可预测植入左心室辅助系统后脱离正性肌力支持的可行性。

• 发表时间: 2010
• 作者: Murata Y;Shishido T;Seguchi O;Yanase M;Fujita T;Toda K;Uemura K;Sugimachi M;Nakatani T.
• 通讯作者: Nakatani T.