The comprehensive study on diagnosis and treatment of minimal deviation adenocarcinoma and related disease of the cervix

本文对112例病例的研究表明，90%以上的腺癌包括小偏差腺癌（MDA）通过磁共振成像（MRI）、巴氏细胞学检查和宫颈锥活检可与宫颈小叶宫颈内腺增生（LEGH）等良性病变鉴别。克隆性分析显示，与MDA或腺癌相关的6个LEGH病变中有4个为单克隆，单克隆LEGH病变中X染色体失活模式与共存的恶性病变相同。STK11突变仅在一种MDA中发现，而在LEGH中未发现。这些结果表明，LEGH的一个亚群可能是包括MDA在内的恶性肿瘤的前体。

Present study of 112 cases demonstrated that over 90% cases of adenocarcinoma including minimal deviation adenocarcinoma (MDA) could be distinguished from benign lesion of the cervix such as lobular endocervical glandular hyperplasia (LEGH) by magnetic resonance imaging (MRI), Papanicolaou cytology and cone biopsy. The clonality analysis revealed that 4 of 6 LEGH lesions associated with MDA or adenocarcinoma were monoclonal, and the patterns of X chromosome inactivation in monoclonal LEGH lesions were identical to those in coexisting malignant lesions. The mutation of STK11 was only identified in one MDA, but not in LEGH. These results indicated that a subset of LEGH may be a precursor to malignant tumors including MDA.