The comprehensive study on diagnosis and treatment of minimal deviation adenocarcinoma and related disease of the cervix

宫颈微小偏差腺癌及相关疾病诊治综合研究

• 批准号: 22591851
• 负责人: MIYAMOTO Tsutomu
• 金额: $ 2.83万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591851/
• 关键词: 悪性腺腫; 分葉状頸管腺過形成; 術前診断; MRI; 細胞診; クローン性; LEGH; 胃型粘液; 組織診断

Present study of 112 cases demonstrated that over 90% cases of adenocarcinoma including minimal deviation adenocarcinoma (MDA) could be distinguished from benign lesion of the cervix such as lobular endocervical glandular hyperplasia (LEGH) by magnetic resonance imaging (MRI), Papanicolaou cytology and cone biopsy. The clonality analysis revealed that 4 of 6 LEGH lesions associated with MDA or adenocarcinoma were monoclonal, and the patterns of X chromosome inactivation in monoclonal LEGH lesions were identical to those in coexisting malignant lesions. The mutation of STK11 was only identified in one MDA, but not in LEGH. These results indicated that a subset of LEGH may be a precursor to malignant tumors including MDA.

本文通过对112例宫颈鳞癌包括微小偏离腺癌(MDA)的磁共振成像(MRI)、巴氏细胞学和锥体活检的研究，证明90%以上的腺癌与小叶性宫颈内腺体增生症(LEGH)等良性宫颈病变相鉴别。克隆性分析显示，6个伴有丙二醛或腺癌的Legh病变中有4个是单克隆性的，且单克隆性Legh病变的X染色体失活模式与共存的恶性病变的X染色体失活模式相同。STK11基因突变仅在1例丙二醛中检测到，而在Legh中未检测到。这些结果表明，LEGH的一个亚群可能是包括丙二醛在内的恶性肿瘤的先兆。

项目成果

Immunohistochemical expression of keratan sulfate: a possible diagnostic marker for carcinomas of the female genital tract

• DOI: 10.1136/jclinpath-2011-200231
• 发表时间: 2011-12-01
• 期刊: JOURNAL OF CLINICAL PATHOLOGY
• 影响因子: 3.4
• 作者: Miyamoto, Tsutomu;Ishii, Keiko;Shiozawa, Tanri
• 通讯作者: Shiozawa, Tanri

産婦人科と乳がん

妇产科和乳腺癌

• 发表时间: 2012
• 作者: Mizutani S;Wright J;Kobayashi H.;中川俊介;塩沢丹里;Miyamoto T;小林浩;中川俊介;宮本 強
• 通讯作者: 宮本 強

Preoperative Differential Diagnosis of Minimal Deviation Adenocarcinoma and Lobular Endocervical Glandular Hyperplasia of the Uterine Cervix A Multicenter Study of Clinicopathology and Magnetic Resonance Imaging Findings

• DOI: 10.1097/igc.0b013e31821f746c
• 发表时间: 2011-10-01
• 期刊: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
• 影响因子: 4.8
• 作者: Takatsu, Akiko;Shiozawa, Tanri;Konishi, Ikuo
• 通讯作者: Konishi, Ikuo

ホルモン療法 (特集 婦人科悪性腫瘍の診断治療アップデート) -- (子宮体がん)

激素治疗（专题：妇科恶性肿瘤诊治进展）——（子宫癌）

• 发表时间: 2012
• 期刊: 産婦人科の実際
• 作者: 芦澤直浩;八幡哲郎;宮本 強
• 通讯作者: 宮本 強

多彩な像を呈した LEGH 病変の 3例

形态各异的LEGH病变3例

• 发表时间: 2012
• 作者: 山田 諭;山田 靖;近藤沙織;橘 涼太;鹿島大靖;宮本 強;岡 賢二;塩沢丹里
• 通讯作者: 塩沢丹里