Exploring novel genes that regulate glycolysis using a genome-wide siRNA library

糖酵解是一个能量产生系统，在许多疾病如癌症和炎症性疾病中起着重要作用。然而，糖酵解是如何调节的仍然不清楚。为了解决这一问题，我们使用全基因组siRNA文库探索了调节糖酵解的新基因，并鉴定了19个新基因。其中一些基因调节癌细胞生长或巨噬细胞功能。因此，我们在这项研究中发现的这些基因可能是癌症或炎症性疾病的治疗靶点。

Glycolysis is a system of energy production which plays an important role in many diseases such as cancer and inflammatory diseases. However, how glycolysis is regulated remains unclear. To address this, we explored novel genes that regulate glycolysis using a genome-wide siRNA library, and identified novel 19 genes. Some of these genes regulate cancer cell growth or macrophage function. Therefore, these genes we identified in this study might be therapeutic targets for cancer or inflammatory diseases.