Investigation of the role of insulin signaling molecules on development of hepatocytes into hepatocytes with fatty changes

我们发现慢性高血糖诱导肝细胞胰岛素受体表达显著增加。我调查了这种变化的机制是否涉及肝脏胰岛素抵抗的恶性循环。首先，我分析了预测与胰岛素受体启动子区域结合的转录因子的蛋白质表达水平，以及慢性高糖刺激下各种胰岛素作用器官的辅因子，但无法确定在这种刺激期间改变其表达水平的蛋白质。现在我正在进一步分析在慢性高糖刺激伴高胰岛素血症期间的变化

We have found that chronic hyperglycemia induced marked increase of insulin receptor expression in the liver cells. I investigated if the mechanism of this change involved in a vicious cycle of hepatic insulin resistance. First, I analyzed protein expression levels of transcription factors predicted to bind with insulin receptor promoter regions and their cofactors of the various insulin acting organs with chronic high glucose stimulation, but could not identify the protein that changed its expression levels during such stimulation. Now I am further analyzing the changes during chronically high glucose stimulation with hyperinsulinemia