Therapeutic and neurophysiological effects of immobilisation followed by motor training in writer´s cramp

固定后进行运动训练对作家痉挛的治疗和神经生理学作用

• 批准号: 5397661
• 负责人: Professor Dr. Günther Deuschl
• 金额: --
• 依托单位: Danish Research Center for Magnetic Resonance
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2003
• 资助国家: 德国
• 起止时间: 2002-12-31 至 2006-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5397661?language=en
• 关键词: Therapeutic; neurophysiological; effects; immobilisation; followed

Writers's cramp (WC) is a task-specific dystonia characterized by involuntary cocontractions during handwriting. So far treatment options for WC are limited. Recent studies have suggested that immobilization or specific motor training of the dystonic limb may be effective in task-specific dystonia. Therefore, the aim of this research proposal is to evaluate the therapeutic effects of immobilization and sensorimotor training of individualized finger movements in WC. Our prediction is that limb immobilization followed by specific training will potentiate and prolong the therapeutic effect as opposed to immobilization alone. The study will include twenty-four patients with WC, which will be randomly assigned to two interventions: (i.) immobilization of the writing hand in a splint for four weeks or (ii.) immobilization of the writing hand followed by specific sensorimotor training. Improvement in handwriting will be the primary outcome measure, which will be assessed both clinically in a blinded fashion and kinematically with a handwriting analysis program. In addition, we will assess dystonia-related sensorimotor dysfunction with transcranial magnetic stimulation and functional brain imaging (EEG and fMRI) before, during and after treatment. This will help to closely link neurophysiologic abnormalities and dystonic symptoms and will provide a framework to guide future treatment strategies for task-specific dystonia.

作家抽筋（WC）是一种任务特异性肌张力障碍，其特征是在书写时不自主收缩。到目前为止，对腹泻的治疗选择有限。最近的研究表明，固定或特定运动训练的张力障碍肢体可能是有效的任务特异性张力障碍。因此，本研究计划的目的是评估固定和个性化手指运动的感觉运动训练对WC的治疗效果。我们的预测是肢体固定之后的特定训练将增强和延长治疗效果，而不是单独固定。这项研究将包括24名WC患者，他们将被随机分配到两种干预措施中：(i)用夹板固定写字的手四周，或（ii）固定写字的手，然后进行特定的感觉运动训练。笔迹的改善将是主要的结果测量，将以盲法临床方式和笔迹分析程序进行运动学评估。此外，我们将在治疗前、治疗中和治疗后通过经颅磁刺激和功能脑成像（EEG和fMRI）评估肌张力障碍相关的感觉运动功能障碍。这将有助于将神经生理异常与肌张力障碍症状紧密联系起来，并将为指导任务特异性肌张力障碍的未来治疗策略提供框架。