Neurophysiological effects of training in visual cognitive tasks

视觉认知任务训练的神经生理学影响

• 批准号: 10403363
• 负责人: CHRISTOS CONSTANTINIDIS
• 金额: $ 45.44万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-03 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10403363
• 关键词: Address; Adult; Age-associated memory impairment; Alzheimer' s Disease; Area; Award; Basic Science; Behavioral; Brain; Cognitive deficits; Cognitive remediation; Complex; Data Set; Disease; Educational Intervention; Goals; Impaired cognition; Individual; Information Storage; Intelligence; Intervention; Knowledge; Language; Liquid substance; Literature; Location; Magic; Maintenance; Memory; Mental disorders; Microelectrodes; Mind; Modeling; Monkeys; Nature; Neurobehavioral Manifestations; Neurons; Noise; Performance; Periodicity; Prefrontal Cortex; Psychological Transfer; Resolution; Role; Sensory; Short-Term Memory; Site; Stimulus; Stroke; Task Performances; Testing; Theoretical Studies; Training; Traumatic Brain Injury; Visual; adjudicate; base; cognitive function; cognitive task; cognitive training; design; experimental study; extrastriate visual cortex; functional restoration; improved; insight; neural correlate; neuronal patterning; neurophysiology; nonhuman primate; normal aging; recruit; relating to nervous system; trait; treatment strategy; visual information; visual stimulus

PROJECT SUMMARY The study will investigate how visual information is represented in the prefrontal cortex, the brain area involved with higher cognitive functions, before and after training to perform a working memory tasks. Monkeys will be trained in cognitive tasks that require them to observe and remember displays with multiple visual stimuli. Neurophysiological recordings with an array of microelectrodes as training progresses will allow us to determine the patterns of neuronal activation that determine the expected improvement in behavioral performance and working memory capacity. The experiments will uncover the nature of changes that take place in the prefrontal cortex during training to perform a working memory task.

项目摘要 这项研究将调查视觉信息是如何在前额叶皮层中表现出来的， 具有较高的认知功能，训练前后可执行工作记忆任务。将猴 接受认知任务的训练，这些任务要求他们观察和记住具有多种视觉刺激的显示。 随着训练的进行，微电极阵列的神经生理记录将使我们能够 确定神经元激活的模式，这些模式决定了行为的预期改善， 工作记忆能力和工作记忆能力。这些实验将揭示 在训练中放置在前额叶皮层，以执行工作记忆任务。