Analysis of the role of CCL17 in wound healing

研究了表皮角质形成细胞产生的CCL17对皮肤免疫、炎症和再生的影响。CCL17通过促进成纤维细胞迁移和募集产生CCR4+ NGF的淋巴细胞和肥大细胞来加速伤口愈合。CCL17可以抑制皮肤中的肿瘤免疫。西替利嗪是一种抗组胺药物，对表皮角质形成细胞和真皮成纤维细胞产生CCL17具有抑制作用。提示CCL17是治疗皮肤创伤的候选药物，CCL17及其受体CCR4的抑制剂可用于预防皮肤炎症后的重塑和治疗皮肤肿瘤。

The effects of CCL17 produced by epidermal keratinocytes on immunity, inflammation and regeneration in the skin were investigated. CCL17 accelerates wound healing by promotion of fibroblast migration and recruitment of CCR4+NGF-producing lymphocytes and mastcytes. CCL17 may suppress tumor immunity in the skin. Cetirizine, an antihistamine drug, has inhibitory effects on CCL17 production by epidermal keratinocytes and dermal fibroblasts. These suggest that CCL17 is a candidate drug for skin wound and inhibitors of CCL17 and its receptor, CCR4, may be available for prevention of remodeling after cutaneous inflammation and treatment for skin tumors.