Analysis of regulatory mechanisms of Notch signaling-induced mast cell maturation and antigen-presenting cell functions

肥大细胞在过敏性炎症性疾病如特应性皮炎和食物过敏的发病机制中起重要作用。我们先前已经表明Notch受体介导的信号传导有助于肥大细胞功能的表达和肥大细胞成熟。在本研究中，我们阐明了Notch信号诱导小鼠骨髓源性肥大细胞的抗原呈递细胞功能和细胞成熟的分子机制。

Mast cells play an important role in the pathogenesis of allergic inflammatory disorders, such as atopic dermatitis and food allergy. We have previously shown that Notch receptor-mediated signaling contributes to expression of mast cell functions and mast cell maturation. In this study, we elucidated the molecular mechanisms by which Notch signaling induces the antigen-presenting cell functions and the cell maturation in mouse bone marrow-derived mast cells.