Induction of chronic metal allergy and participate in intrinsic atopic dermatitis.

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Two types of atopic dermatitis(AD) have been proposed, the extrinsic tyoe shows high IgE levels and the intrinsic type exhibits normal IgE levels. Because I understood that the positive percentage of the metal patch test was high in intrinsic AD. I made the allergy to metal onset model mouse. However, I performed reexamination pro-experiment because individual difference was big, and the mice which were not established had much sensitization. I examined the laboratory procedure of the allergy to metal afterwards.