Induction of chronic metal allergy and participate in intrinsic atopic dermatitis.

已经提出了两种类型的特应性皮炎(AD)，外源性类型表现出高IgE水平，而内在类型表现出正常IgE水平。因为我了解到，内在AD中金属斑贴试验的阳性率很高。我制作了金属过敏发作模型小鼠。但由于个体差异较大，未建立的小鼠致敏性较大，因此在实验前进行了复检。后来我检查了金属过敏的实验室程序。

Two types of atopic dermatitis(AD) have been proposed, the extrinsic tyoe shows high IgE levels and the intrinsic type exhibits normal IgE levels. Because I understood that the positive percentage of the metal patch test was high in intrinsic AD. I made the allergy to metal onset model mouse. However, I performed reexamination pro-experiment because individual difference was big, and the mice which were not established had much sensitization. I examined the laboratory procedure of the allergy to metal afterwards.