A response of pre-immune system of epidermal keratinocytes

获得性免疫控制接触性皮炎，已知表皮角质形成细胞在其中起作用。然而，目前尚不清楚接触性皮炎的免疫反应是如何开始的。这项研究表明，在没有其他免疫细胞的情况下，表皮角质形成细胞能够通过纳米材料二氧化钛的机械刺激而引起炎症。我们经常会因为刺激物的刺激而患上皮炎，有趣的是，同样的反应也发生在个别的表皮细胞中。

The acquired immunity controls contact dermatitis, and it is known that the epidermal keratinocytes play a part in that. However, it is not clear how the immune reaction of the contact dermatitis starts. This study showed that the epidermal keratinocytes, without other immune cells, are able to cause inflammation by mechanical irritation of nanomaterial TiO2. We often have dermatitis by irritation of prickly thing, interestingly, the same response occurs in individual epidermal cells.