Clinical and basic study of the effect of microvascular blood flow to normal tissue radiosensitivity

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Laser Doppler flowmeter was used to measure normal skin microvascular blood flow before and after irradiation, and degrees of spatial and temporal changes and adverse events were also analysed. Changes in the microvascular blood flow of the irradiated skin were associated with the degree of acute adversed event, but not with the non-irradiated skin(=normal tissue blood flow). Although, late adversed event such as subcutaneous edema, had trend of correlation with microvascular blood flow. There was no correlation between parotid gland dysfunction(xerostomia) and microvascular blood flow.