Clinical and basic study of the effect of microvascular blood flow to normal tissue radiosensitivity

微血管血流对正常组织放射敏感性影响的临床与基础研究

• 批准号: 22791226
• 负责人: IZUMI Sachiko
• 金额: $ 2.66万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791226/
• 关键词: 放射線腫瘍学; 末梢血流動態; 放射線治療; レーザー血流計; 急性有害事象; 晩期有害事象; 正常組織障害

Laser Doppler flowmeter was used to measure normal skin microvascular blood flow before and after irradiation, and degrees of spatial and temporal changes and adverse events were also analysed. Changes in the microvascular blood flow of the irradiated skin were associated with the degree of acute adversed event, but not with the non-irradiated skin(=normal tissue blood flow). Although, late adversed event such as subcutaneous edema, had trend of correlation with microvascular blood flow. There was no correlation between parotid gland dysfunction(xerostomia) and microvascular blood flow.

采用激光多普勒血流仪检测正常皮肤微血管血流在照射前后的变化，并分析其时空变化程度及不良反应。照射皮肤微血管血流的变化与急性不良事件的程度相关，但与非照射皮肤（=正常组织血流）无关。但晚期不良事件如皮下水肿与微血管血流有相关趋势。腮腺功能障碍（口干）与微血管血流无相关性。

项目成果

中咽頭癌に対する強度変調放射線(IMRT)治療中の耳下腺容積と照射線量の変化

口咽癌调强放射（IMRT）治疗期间腮腺体积和放射剂量的变化

• 发表时间: 2011
• 作者: 泉佐知子;秋元哲夫;他7名
• 通讯作者: 他7名

【頭頸部癌診療の今】放射線治療の進歩高精度放射線治療強度変調放射線治療を中心に

【头颈癌治疗现状】放疗进展 高精度放疗 聚焦调强放疗

• 发表时间: 2011
• 期刊: Pharma Medica
• 作者: 泉佐知子;三橋紀夫
• 通讯作者: 三橋紀夫