PET imaging of neural specific cell adhesion molecule as an indication of axonal regeneration

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In the case of peripheral nerve disorder and spinal cord injury, extent of nerve damage and regeneration ability are important for decision of treatment strategy and, therefore, development of molecular probes useful for getting these information is urgently required. In this study, I synthesized peptide ligand derivatives against neural cell adhesion molecule(NCAM), or^<64> Cu-labeled PET probes, and performed PET study using NCAM expressing tumor bearing mice. Additively, I successfully synthesized dendron type PET probes for improvement of affinity and biodistribution by the effect of multimerization and increase of molecular weight.