Establishment of radio sensitivity assay with a novel primary culture system from cancer patients

利用癌症患者的新型原代培养系统建立放射敏感性测定

• 批准号: 22791240
• 负责人: ENDO Hiroko
• 金额: $ 2.58万
• 依托单位: Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791240/
• 关键词: 放射線腫瘍学; 癌細胞初代培養; 放射線感受性試験

We reported a novel primary culture system, Cancer Tissue-Originated S heroid (CTOS) method. In the present study, we tried to establish the radio sensitivity assay using CTOSs from lung cancer patients. CTOSs from different patients showed a variety of radiosensitivitiy, which reflected the therapeutic effect in mice tunlors. CTOS would be applicable for predicting individual radio sensitivity.

我们报道了一种新的原代培养系统，癌组织源性类肉瘤（CTOS）方法。本研究尝试建立肺癌患者CTOS的放射敏感性测定方法。不同患者CTOS的放射敏感性不同，反映了CTOS在小鼠体内的治疗效果。CTOS可用于预测个体放射敏感性。

项目成果

Hypoxia-induced tumor dormancy promotes cell survival through supPression of energy metabolism

缺氧诱导的肿瘤休眠通过抑制能量代谢促进细胞存活

• 发表时间: 2012
• 作者: Kondo J;Endo H;Okuyama H;Ishikawa O;Iishi H;Tsujii M;Ohue M;and Inoue M;Jumpei Kondo;遠藤洋子
• 通讯作者: 遠藤洋子

Prediction of therapeutic effect of EGFR TKI on lung cancer by a novel primary culture system

新型原代培养系统预测EGFR TKI对肺癌的治疗效果

• 发表时间: 2011
• 作者: Kondo J;Endo H;Okuyama H;Ishikawa O;Iishi H;Tsujii M;Ohue M;and Inoue M;Jumpei Kondo;遠藤洋子;遠藤洋子;遠藤洋子
• 通讯作者: 遠藤洋子

Retaining cell-cell contact enables preparation and culture of spheroids composed of pure primary cancer cells from colorectal cancer

• DOI: 10.1073/pnas.1015938108
• 发表时间: 2011-04-12
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Kondo, Jumpei;Endo, Hiroko;Inoue, Masahiro
• 通讯作者: Inoue, Masahiro

A novel primary culture system of cancer cells from lung cancer patients

肺癌患者癌细胞的新型原代培养系统

• 发表时间: 2010
• 作者: Kondo J;Endo H;Okuyama H;Ishikawa O;Iishi H;Tsujii M;Ohue M;and Inoue M;Jumpei Kondo;遠藤洋子;遠藤洋子;遠藤洋子;遠藤洋子
• 通讯作者: 遠藤洋子

Analysis of radiosensitivity mechamisms in cervical cancer CTOS

宫颈癌CTOS放射敏感性机制分析

• 作者: Kondo J;Endo H;Okuyama H;Ishikawa O;Iishi H;Tsujii M;Ohue M;and Inoue M;Jumpei Kondo;遠藤洋子;遠藤洋子;遠藤洋子;遠藤洋子;遠藤 洋子;中嶋 綾
• 通讯作者: 中嶋 綾