The elucidation of new immunity Paragram Treg/Th17 balance in the gastrointestinal carcinoma

胃肠癌中新免疫Paragram Treg/Th17平衡的阐明

• 批准号: 22791296
• 负责人: IIDA Takeshi
• 金额: $ 1.41万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791296/
• 关键词: Th17; Treg; 腫瘍; IL-17; Foxp3

In the examination of the tumor growth curve in the mouse in vivo subcutaneous tumor model, in the mIL-17A-shRNA group, it significantly showed tumor growth depression effect as compared with the PBS group of the control SNC group.It was suggested that IL-17 acted as a tumor growth factor in the tumor microenvironment.

在小鼠体内皮下肿瘤模型的肿瘤生长曲线检查中，与对照SNC组的PBS组相比，mIL-17 A-shRNA组显示出显著的肿瘤生长抑制作用，提示IL-17在肿瘤微环境中起肿瘤生长因子的作用。

项目成果

Prognostic significance of IL-17 mRNA expression in peritoneal lavage detected by real-time RT-PCR in gastric cancer

实时RT-PCR检测腹腔灌洗液中IL-17 mRNA表达对胃癌的预后意义

• 发表时间: 2011
• 作者: Umehara S;Shiozaki A;Otsuji E;et al;飯田武
• 通讯作者: 飯田武

Tumor-infiltrating CD4+ Th17 cells produce IL-17 in tumor microenvironment and promote tumor progression in human gastric cancer

• DOI: 10.3892/or.2011.1201
• 发表时间: 2011-05-01
• 期刊: ONCOLOGY REPORTS
• 影响因子: 4.2
• 作者: Iida, Takeshi;Iwahashi, Makoto;Yamaue, Hiroki
• 通讯作者: Yamaue, Hiroki

胃癌腫瘍局所におけるIL-17の発現解析と腫瘍増殖との関連

局部胃癌肿瘤中IL-17的表达及其与肿瘤生长的关系分析

• 发表时间: 2010
• 作者: Okabe H;Beppu T;Ueda M;Hayashi H,Ishiko T;Masuda T;Otao R;Horlad H,Mima K;Miyake K;Iwatsuki M;Baba Y,Takamori H;Jono H;Shinriki S;AndoY;Baba H;飯田武
• 通讯作者: 飯田武

Vaccination with peptides derived from cancer-testis antigens in combination with CpG-7909 elicits strong specific CD8+T cell response in patients with metastatic esophageal squamous cell carcinoma

• DOI: 10.1111/j.1349-7006.2010.01732.x
• 发表时间: 2010-12-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Iwahashi, Makoto;Katsuda, Masahiro;Yamaue, Hiroki
• 通讯作者: Yamaue, Hiroki

胃癌腹腔洗浄液中におけるIL-17mRNAの発現解析

胃癌腹腔灌洗液中IL-17 mRNA的表达分析

• 发表时间: 2011
• 作者: Shiozaki A;Fujiwara H;Otsuji E;et al;鹿島理沙;飯田武
• 通讯作者: 飯田武