The elucidation of IL-17/IL-21 axis and new immunotherapy in tumor microenvironment

我们检测了胃癌患者腹腔灌洗液中IL-17mRNA的表达水平，并探讨了其表达与临床病理参数和预后的关系。IL-17mRNA的表达与肿瘤的侵袭深度有关，根治性切除患者的生存曲线明显好于IL-17mRNA低表达的患者。多因素分析显示，腹腔液中IL-17mRNA的低表达和肿瘤大小是独立的有意义的预后因素，实时定量RT-PCR检测腹腔液中IL-17mRNA的表达是胃癌根治性切除患者可靠的预后因素。IL-17基因在腹膜腔内的低表达可能与胃癌患者腹膜腔内肿瘤的发生有关。

We investigated the expression level of IL-17 mRNA in peritoneal lavage with gastric cancer patients and assessed the association of its expression with clinicopathological parameters and prognosis. IL-17 mRNA expression was associated with the depth of the invasion.The survival curves in patients who underwent curative resection showing high expression of IL-17 mRNA were significantly better than that in patients showing low expression of IL-17 mRNA. In a multivariate analysis, IL-17 mRNA-low expression in peritoneal lavage and tumor size were independent significant predictive factors for prognosis.IL-17 mRNA expression in peritoneal lavage detected by real-time RT-PCR is a reliable prognostic factor in patients with curative resection in gastric cancer. Low IL-17 gene expression in the peritoneal cavity may correlate with cancer development in the peritoneal cavity in patients with gastric cancer.