The elucidation of IL-17/IL-21 axis and new immunotherapy in tumor microenvironment

肿瘤微环境中IL-17/IL-21轴的阐明和新的免疫治疗

• 批准号: 24791446
• 负责人: IIDA Takeshi
• 金额: $ 1.66万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791446/
• 关键词: 胃癌; 腫瘍; IL-17; 腹腔; 癌; サイトカイン

We investigated the expression level of IL-17 mRNA in peritoneal lavage with gastric cancer patients and assessed the association of its expression with clinicopathological parameters and prognosis. IL-17 mRNA expression was associated with the depth of the invasion.The survival curves in patients who underwent curative resection showing high expression of IL-17 mRNA were significantly better than that in patients showing low expression of IL-17 mRNA. In a multivariate analysis, IL-17 mRNA-low expression in peritoneal lavage and tumor size were independent significant predictive factors for prognosis.IL-17 mRNA expression in peritoneal lavage detected by real-time RT-PCR is a reliable prognostic factor in patients with curative resection in gastric cancer. Low IL-17 gene expression in the peritoneal cavity may correlate with cancer development in the peritoneal cavity in patients with gastric cancer.

我们检测了胃癌患者腹腔灌洗液中IL-17mRNA的表达水平，并探讨了其表达与临床病理参数和预后的关系。IL-17mRNA的表达与肿瘤的侵袭深度有关，根治性切除患者的生存曲线明显好于IL-17mRNA低表达的患者。多因素分析显示，腹腔液中IL-17mRNA的低表达和肿瘤大小是独立的有意义的预后因素，实时定量RT-PCR检测腹腔液中IL-17mRNA的表达是胃癌根治性切除患者可靠的预后因素。IL-17基因在腹膜腔内的低表达可能与胃癌患者腹膜腔内肿瘤的发生有关。

项目成果

胃癌腹腔洗浄液中におけるIL-17mRNAの発現解析

胃癌腹腔灌洗液中IL-17 mRNA的表达分析

• 发表时间: 2011
• 作者: Shiozaki A;Fujiwara H;Otsuji E;et al;鹿島理沙;飯田武
• 通讯作者: 飯田武

Antitumor immune response of dendritic cells (DCs) expressing tumor-associated antigens derived from induced pluripotent stem cells: In comparison to bone marrow-derived DCs

• DOI: 10.1002/ijc.28367
• 发表时间: 2014-01-15
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Iwamoto, Hiromitsu;Ojima, Toshiyasu;Yamaue, Hiroki
• 通讯作者: Yamaue, Hiroki

Prognostic significance of IL-17 mRNA expression in peritoneal lavage in gastric cancer patients who underwent curative resection

• DOI: 10.3892/or.2013.2911
• 发表时间: 2014-02-01
• 期刊: ONCOLOGY REPORTS
• 影响因子: 4.2
• 作者: Iida, Takeshi;Iwahashi, Makoto;Yamaue, Hiroki
• 通讯作者: Yamaue, Hiroki