The elucidation of IL-17/IL-21 axis and new immunotherapy in tumor microenvironment

我们研究IL-17 mRNA在胃癌患者腹腔灌洗液中的表达水平，并评估其表达与临床病理参数及预后的关系。IL-17 mRNA表达与侵袭深度相关。IL-17 mRNA高表达的根治性切除患者的生存曲线明显优于IL-17 mRNA低表达的患者。在多因素分析中，IL-17 mrna在腹腔灌洗中的低表达和肿瘤大小是影响预后的独立显著预测因素。实时RT-PCR检测腹腔灌洗液中IL-17 mRNA表达是胃癌根治性切除患者预后的可靠指标。胃癌患者腹腔IL-17基因的低表达可能与腹腔肿瘤的发生有关。

We investigated the expression level of IL-17 mRNA in peritoneal lavage with gastric cancer patients and assessed the association of its expression with clinicopathological parameters and prognosis. IL-17 mRNA expression was associated with the depth of the invasion.The survival curves in patients who underwent curative resection showing high expression of IL-17 mRNA were significantly better than that in patients showing low expression of IL-17 mRNA. In a multivariate analysis, IL-17 mRNA-low expression in peritoneal lavage and tumor size were independent significant predictive factors for prognosis.IL-17 mRNA expression in peritoneal lavage detected by real-time RT-PCR is a reliable prognostic factor in patients with curative resection in gastric cancer. Low IL-17 gene expression in the peritoneal cavity may correlate with cancer development in the peritoneal cavity in patients with gastric cancer.