Liver regeneration by means of partial splenic embolization(PSE)-associated with autologous bone marrow cell transplantation-

通过部分脾栓塞（PSE）与自体骨髓细胞移植相关的肝再生

• 批准号: 22791215
• 负责人: YAMAMOTO Akira
• 金额: $ 2.5万
• 依托单位: Osaka City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791215/
• 关键词: 再生医学; 放射線

In this study, we were able to make a rabbit model with chronic liver damage. We confirmed significant fibrosis of the liver. We obtained adequate bone marrow stem cells of rabbit and purified bone marrow contains mesenchymal stem cells. We inserted catheter and infused normal saline to the rabbit in the control group, embolized splenic artery, infused stem cells, and embolized splenic artery and infused bone marrow cells. We confirmed the improvement of the serum bilirubin in the bone marrow plus PSE group ; however many rabbits died. This was considered to be over stress to the rabbit with chronic liver damage model.

本研究建立了家兔慢性肝损伤模型。我们确认了肝脏纤维化。获得了足量的兔骨髓干细胞，纯化后的骨髓中含有间充质干细胞。对照组置管灌注生理盐水，栓塞脾动脉灌注干细胞，栓塞脾动脉灌注骨髓细胞。我们证实了骨髓加PSE组的血清胆红素有所改善，但许多家兔死亡。认为这是对慢性肝损伤模型家兔的过度应激。