Development of bifunctional colon-specific delivery system of prednisolone using chitosan capsules and inhibitors of efflux transporters
Development of bifunctional colon-specific delivery system of prednisolone using chitosan capsules and inhibitors of efflux transporters
批准号:
18390055
负责人:
YAMAMOTO Akira
金额:
$10.6万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2006
资助国家:
日本
项目状态:
已结题
起止时间:
2006 至 2007
中文摘要
在这项研究中,我们考察了壳聚糖胶囊在大鼠结肠定位释放强的松龙的有效性。并与常规剂型(明胶胶囊)比较,评价壳聚糖胶囊与常规剂型(明胶胶囊)治疗强的松龙的疗效和不良反应。与明胶胶囊相比,壳聚糖胶囊口服泼尼松龙后,大鼠大肠粘膜中强的松龙浓度显著增加。而口服壳聚糖胶囊后的强的松龙血药浓度明显低于明胶胶囊。我们还通过测定线粒体过氧化物酶(MPO)活性和结肠湿重/体重(C/B)比率来评价强的松龙对三硝基苯磺酸(TNBS)诱导的结肠炎愈合的疗效。与明胶胶囊相比,用壳聚糖胶囊口服强的松龙后,MPO活性和C/B比值显著降低。此外,用明胶胶囊口服强的松龙后,胸腺重量明显减少,而用壳聚糖胶囊口服强的松龙后,胸腺重量变化不大。这些结果表明,壳聚糖胶囊可能有助于强的松龙的结肠定位释放,并增强其对结肠炎的愈合作用。此外,壳聚糖胶囊还可能有效地减少强的松龙的副作用,因为它减少了肠道对体循环的转移。
英文摘要
In this study, we examined the effectiveness of chitosan capsules for the colon-specific delivery of prednisolone in rats. We also evaluated the effectiveness and side effect of prednisolone using chitosan capsules compared with the conventional dosage form (gelatin capsules). We found a significant increase in the concentration of prednisolone in the large intestinal mucosa when prednisolone was administered orally using chitosan capsules, as compared with the case using gelatin capsules. On the other hand, the plasma concentrations of prednisolone after oral administration using chitosan capsules were much lower than those in the case of gelatin capsules. We also assessed the effectiveness of prednisolone for the healing of trinitrobenzene sulfonic acid (TNBS)-induced colitis by measuring the rnyeloperoxidase (MPO) activities and colon wet weight/body weight (C/B) ratios. The MPO activities and C/B ratios significantly reduced when prednisolone was administered orally using chitosan capsules, in comparison with the case of gelatin capsules. Moreover, the weight of thymus, which is an index of side effect of prednisolone, remarkably decreased after oral administration of prednisolone using gelatin capsules, whereas its weight was not so much changed when prednisolone was administered orally using chitosan capsules.These findings indicated that chitosan capsules might be useful for the colon specific delivery of prednisolone and its enhanced effectiveness for the healing of colitis in rats. Moreover, chitosan capsules might be also effective for reducing the side-effect of prednisolone due to its decreased intestinal transfer to the systemic circulation.
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会议论文
キトサンカプセル剤を用いたプレドニゾロンの大腸送達法の開発に関する研究
壳聚糖胶囊泼尼松龙结肠给药方法的研究
DOI:
--
发表时间:
2007
期刊:
薬学雑誌 127
影响因子:
--
作者:
[服部祐紀, 他2名, 山本 昌]
通讯作者:
山本 昌
Study on the Colon Specific Delivery of Prednisolone Using Chitosan Capsules
壳聚糖胶囊泼尼松龙结肠特异性给药的研究
DOI:
10.1002/chin.200732276
发表时间:
2007
期刊:
影响因子:
--
作者:
[A. Yamamoto]
通讯作者:
A. Yamamoto
キトサンカプセルを用いたプレドニゾロンの大腸特異的送達法の開発に関する研究
壳聚糖胶囊泼尼松龙结肠特异性给药方法的研究
DOI:
--
发表时间:
2007
期刊:
薬学雑誌 127
影响因子:
--
作者:
[Wang, G., 山本 昌]
通讯作者:
山本 昌
Polymerization characteristics control using the modality laserspeckle analysis
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批准号:23792189
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$1.58万
-
财政年份:2011
-
负责人:YAMAMOTO Akira
-
依托单位:
Brain atlas using ultra high resolution DTI and SWI
-
批准号:23591765
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
-
财政年份:2011
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负责人:YAMAMOTO Akira
-
依托单位:
Liver regeneration by means of partial splenic embolization(PSE)-associated with autologous bone marrow cell transplantation-
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批准号:22791215
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.5万
-
财政年份:2010
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负责人:YAMAMOTO Akira
-
依托单位:
Development of novel transdermal delivery formulation of incretin using biodegradable microneedle arrays
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批准号:22590155
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2010
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负责人:YAMAMOTO Akira
-
依托单位:
Development of Postmortem Diagnostic Imaging Method Using 3-T MRI
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批准号:21200020
-
项目类别:Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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资助金额:$19.05万
-
财政年份:2009
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负责人:YAMAMOTO Akira
-
依托单位:
Ultra high resolution diffusion tensor imaging atlas using 3T MRI with 32ch coil
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批准号:21791186
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.75万
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财政年份:2009
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负责人:YAMAMOTO Akira
-
依托单位:
Search for Primordial Antiparticle with a balloon-borne experiment using a superconducting spectrometer at a solar minimum period
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批准号:18104006
-
项目类别:Grant-in-Aid for Scientific Research (S)
-
资助金额:$66.73万
-
财政年份:2006
-
负责人:YAMAMOTO Akira
-
依托单位:
Delivery of genomic protein drug using the chemical modification with basic peptide and biodegradable minicapsules
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批准号:16590128
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2004
-
负责人:YAMAMOTO Akira
-
依托单位:
Search for cosmic-ray antiparticles of primary origins by ballooning a superconducting spectrometer in Antarctica
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批准号:13001004
-
项目类别:Grant-in-Aid for Specially Promoted Research
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资助金额:$333.63万
-
财政年份:2001
-
负责人:YAMAMOTO Akira
-
依托单位:
Functional modulation of drug efflux system by drug interaction and development of oral drug delivery system
-
批准号:12672231
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.5万
-
财政年份:2000
-
负责人:YAMAMOTO Akira
-
依托单位:
The Validity of Indices for Preservation District Zoning-Historical TownScape Comparison Between Japan and the other Country
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批准号:11650636
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:1999
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负责人:YAMAMOTO Akira
-
依托单位:
BESS Experiment to Search for Cosmic Ray Antiparticle
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批准号:08044102
-
项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$4.16万
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财政年份:1996
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负责人:YAMAMOTO Akira
-
依托单位:
INNOVATION IN ROTATIONAL PANORAMIC RADIOGRAPHIC UNIT BY FAST SCANNING.
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批准号:08407061
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$13.76万
-
财政年份:1996
-
负责人:YAMAMOTO Akira
-
依托单位:
Search for Primordial Antiparticle with a Superconducting Magnet Spectrometer in Ballooning
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批准号:06402008
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$22.14万
-
财政年份:1994
-
负责人:YAMAMOTO Akira
-
依托单位:
Search for Matter/Antimatter in Early Universe
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批准号:05044064
-
项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$6.72万
-
财政年份:1993
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负责人:YAMAMOTO Akira
-
依托单位:
MOLECULAR-GENETIC STUDY OF FAMILIAR HYPERLIPOPROTEINEMIA RELATED TO ATHEROSCLEROSIS
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批准号:05454326
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项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$4.16万
-
财政年份:1993
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负责人:YAMAMOTO Akira
-
依托单位:
PREVENTION OF PERITONEAL METASTASIS -INHIBITION OF VASEMENT MEMBRANE DESTRUCTION
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批准号:03670617
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$0.9万
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财政年份:1991
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负责人:YAMAMOTO Akira
-
依托单位:
OBSERVATION OF HIGH ENERGY COSMIC-RAY WITH SUPERCONDUCTING SPECTROMETER
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批准号:02044151
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项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$12.8万
-
财政年份:1990
-
负责人:YAMAMOTO Akira
-
依托单位:
海外基金