Role of innate immune signaling in the development of idiopathic osteonecrosis of the femoral head

本研究的目的是建立特发性股骨头坏死的动物模型，并阐明先天免疫信号在特发性股骨头坏死发生发展中的作用。因此，我们可以阐明以下认识：(1)负重不利于激素性股骨头坏死的发生；(2)可以建立酒精性股骨头坏死的动物模型；(3)通过Toll样受体激活天然免疫信号是激素性股骨头坏死发生所必需的；(4)IRF7和核因子-kB激活的相对差异导致股骨头坏死的发生。(5)肝脏对糖皮质激素治疗无反应可能与临床股骨头坏死的发病机制有关。这些结果将有助于我们今后阐明特发性股骨头坏死的发病机制。

The aims of present study were to establish animal models of idiopathic osteonecrosis, and to clarify role of innate immune signaling in the development of idiopathic osteonecrosis of the femoral head. As a result, we could clarify these insights as follows :(1) weightbearing dose not contribute to the development of corticosteroid-induced osteonecrosis of the femoral head,(2) we could developed animal model of alcohol-induced osteonecrosis of the femoral head,(3) activation of innate immune signaling via toll-like receptor is require to develop corticosteroid-induced osteonecrosis of the femoral head,(4) relative differences in the activation of IRF7 and NF-kB lead to the development of osteonecrosis of the femoral head,(5) absence of any response to corticosteroid therapy in the liver may be implicated in the pathogenesis of osteonecrosis of the femoral head in clinically. These results will help us in the future to elucidate the pathogenesis of idiopathic osteonecrosis of the femoral head.