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Milrinone and levosimendan administered after reperfusion improve myocardial stunning in swine

Milrinone and levosimendan administered after reperfusion improve myocardial stunning in swine
再灌注后施用米力农和左西孟旦可改善猪的心肌顿抑
批准号:
22791440
负责人:
SHIBATA Itsuko
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
We assessed the effect of milrinone application timing after reperfusion against myocardial stunning as compared with levosimendan in swine. Furthermore, we examined the role of p38 mitogen-activated protein kinase (p38 MAPK) in the milrinone-induced cardioprotection. Milrinone should be administered just after reperfusion to protect myocardial stunning through p38 MAPK, whereas levosimendan improvement of contractile function could be mainly dependent on its positive inotropic effect
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Administration of the levosimendan 20-min after Reperfusion Improves Stunned Myocardium in Swine.
再灌注后 20 分钟给予左西孟旦可改善猪的心肌顿抑。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Maekawa T, Cho S, Ichinomiya T, TosakaS, Matsumoto S, Shibata I, Hara T, Sumikawa K, Itsuko Shibata, Itsuko Shibata, Itsuko Shibata]
通讯作者: Itsuko Shibata
Milrinone and levosimendan administered after reperfusion improve myocardial stunning in swine.
再灌注后给予米力农和左西孟旦可改善猪的心肌顿抑。
DOI: 10.3109/14017431.2012.732236
发表时间: 2013
期刊: Scand Cardiovasc J.
影响因子: --
作者: [Kawahito S, Higuchi S, Mita N, Kitagawa T, Kitahata H, 中條浩介,簗瀬賢,植村直哉,武田敏宏,岡部悠吾,澤登慶治,古泉真理,佐野愛,宮脇有紀,白神豪太郎., Shibata Itsuko]
通讯作者: Shibata Itsuko
A p38 MAPK inhibitor, SB203580, blocks cardioprotective effect of post-ischemic administration of milrinone against myocardial stunning in swine
p38 MAPK 抑制剂 SB203580 可阻断缺血后施用米力农对猪心肌顿抑的心脏保护作用
DOI: --
发表时间: 2010
期刊: Anesthesiology
影响因子: 8.8
作者: [Shibata I, Yo shi t o mi O, Sakai K, Maekawa T, Cho S, Sumikawa K]
通讯作者: Sumikawa K
Administration of the levosimendan 20-min after Reperfusion Improves Stunned Myocardium in Swine
再灌注 20 分钟后给予左西孟旦可改善猪的心肌顿抑
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Maekawa T, Cho S, Ichinomiya T, TosakaS, Matsumoto S, Shibata I, Hara T, Sumikawa K, Itsuko Shibata, Itsuko Shibata]
通讯作者: Itsuko Shibata
6
    GLP-1 receptor agonists protect myocardium against ischemia-reperfusion injury
    • 批准号:
      16K10966
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.08万
    • 财政年份:
      2016
    • 负责人:
      SHIBATA Itsuko
    • 依托单位:
    Effects of the glucagon-like peptide-1 receptor agonist on the functional recovery of myocardial stunning in pigs.
    • 批准号:
      25462441
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.16万
    • 财政年份:
      2013
    • 负责人:
      SHIBATA Itsuko
    • 依托单位:
    Administration of the Rho-kinase inhibitor Fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine.
    • 批准号:
      20791079
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.66万
    • 财政年份:
      2008
    • 负责人:
      SHIBATA Itsuko
    • 依托单位:
    海外基金