Administration of the Rho-kinase inhibitor Fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine.

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We assessed the effect of administration time for fasudil treatment of the stunned myocardium in 40 anesthetized open chest swine. Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in anesthetized open-chest swine. This cardioprotective effect of fasudil against myocardial stunning was probably not related to systemic or coronary hemodynamic changes. Rho-kinase inhibition during early reperfusion could therefore protect against myocardial stunning.