Can GABA agonist improve nocturia symptoms?-basic research to elucidate the relationship between sleep and bladder function

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Intravenous melatonin administration was found to significantly increase intercontraction interval in 24-month-old rats, however, it did not affect micturition voiding pressure, basal pressure, pressure threshold. It showed no significant changes in 10-week-old rats. Electroencephalographic findings showed that melatonin did not influence relative power values in either group. Melatonin increased bladder capacity without affecting bladder pressure in 24-month-old rats and can therefore be expected to be beneficial for treating nocturia in the elderly.