Study on the serotypes and specific immune response of Streptococcus pneumonia in acute otitis media.

急性中耳炎肺炎链球菌血清型及特异性免疫应答研究

• 批准号: 22791624
• 负责人: IKEDA Yorihiko
• 金额: $ 2.5万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791624/
• 关键词: 急性中耳炎; 肺炎球菌; 血清型

Streptococcus pnenmoniae is a leading cause of acute otitis media. S. pnenmoniae typically colonizes the human nasopharynx. Among 202 S. pnenmoniae isolates from the uuper respiratory tract infections(URT), we were determined serotype 19F(19. 4%), serotype 23F(14. 9%), serotype 14(11. 4%), serotype 6B(11. 4%), serotype 6A(9. 1%), serotype 3(9. 1%). All strains of serotype 3 were penicillin susceptible S. pnenmoniae(PSSP), on the other hand, strains of serotype 19F and serotype 23F were predominant in penicillin resistant S. pnenmoniae(PRSP) or penicillin intermediately resistant S. pnenmoniae(PISP). The coverage of S. pnenmoniae vaccine were 7-valent pneumococcal conjugate vaccine(7-PCV, 60. 6%), 11-PCV(61. 7%), 13-PCV(82. 9%), PPV(82. 9%) respectively.

肺炎链球菌是引起急性中耳炎的主要原因。肺炎链球菌通常在人类鼻咽部定植。从上呼吸道感染(URT)分离出202株肺炎链球菌，其中19F型占19.4%，23F型占14.9%，14型占11.4%，6B型占11.4%，6A型占9.1%，3型占9.1%。血清3型均为青霉素敏感肺炎链球菌(PSSP)，而青霉素耐药肺炎链球菌(PRSP)和青霉素中耐药肺炎链球菌(PISP)以19F型和23F型为主。肺炎链球菌疫苗的接种率为7价肺炎球菌结合疫苗(7-PCV，60。6%)、11-PCV(61.7%)，13-PCV(82.9%)，PPV(82%。9%)。