Study on the serotypes and specific immune response of Streptococcus pneumonia in acute otitis media.

肺炎链球菌是导致急性中耳炎的主要原因。S.肺炎支原体通常定殖于人鼻咽。在202个S.从1999年1月至1999年12月间的呼吸道感染（URT）中分离到19 F（19. 4%）、血清型23 F（14. 9%）、血清型14（11. 4%）、血清型6 B（11. 4%）、血清型6A（9. 1%）、血清3型（9. 1%）。血清3型均为青霉素敏感株。青霉素耐药菌株以19 F和23 F型为主。pnenmoniae（PRSP）或青霉素中度耐药S. pnenmoniae（PISP）。S.肺炎球菌疫苗为7价肺炎球菌结合疫苗（7-PCV，60. 6%）、11-PCV（61. 7%）、13-PCV（82. 9%）、PPV（82. 9%）。

Streptococcus pnenmoniae is a leading cause of acute otitis media. S. pnenmoniae typically colonizes the human nasopharynx. Among 202 S. pnenmoniae isolates from the uuper respiratory tract infections(URT), we were determined serotype 19F(19. 4%), serotype 23F(14. 9%), serotype 14(11. 4%), serotype 6B(11. 4%), serotype 6A(9. 1%), serotype 3(9. 1%). All strains of serotype 3 were penicillin susceptible S. pnenmoniae(PSSP), on the other hand, strains of serotype 19F and serotype 23F were predominant in penicillin resistant S. pnenmoniae(PRSP) or penicillin intermediately resistant S. pnenmoniae(PISP). The coverage of S. pnenmoniae vaccine were 7-valent pneumococcal conjugate vaccine(7-PCV, 60. 6%), 11-PCV(61. 7%), 13-PCV(82. 9%), PPV(82. 9%) respectively.