Analysis of ZNF143 as a Th2 cytokine regulator in allergic rhinitis

ZNF143作为变应性鼻炎Th2细胞因子调节剂的分析

• 批准号: 22791640
• 负责人: WAKASUGI Tetsuro
• 金额: $ 1.66万
• 依托单位: University of Occupational and Environmental Health, Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791640/
• 关键词: 転写因子; ZNF143; Th2サイトカイン; アレルギー性鼻炎; 好酸球

The expression level of ZNF143 mRNA in human nasal mucosa had significant correlation between IL-5 mRNA, IL-13 mRNA, and the total IgE. This is the result of showing that ZNF143 is participating in the allergic rhinitis through the transcriptional regulation of Th2 cytokines. We consider ZNF143 interacts with GATA-3 and involved in the regulation of the Th2 cytokines.

人鼻粘膜ZNF 143 mRNA表达水平与IL-5 mRNA、IL-13 mRNA表达水平及总IgE呈显著相关。这表明ZNF 143通过对Th 2细胞因子的转录调控参与变应性鼻炎的发生。我们认为ZNF 143与加塔-3相互作用并参与Th 2细胞因子的调节。

项目成果

Expression of epidermal growth factors, erbBs, in the nasal mucosa of patients with chronic hypertrophic rhinitis.

慢性肥厚性鼻炎患者鼻粘膜中表皮生长因子 erbB 的表达。

• DOI: 10.1159/000335583
• 发表时间: 2012
• 期刊: ORL J otorhinolaryngol Relat Spec.
• 作者: 岡秀樹;都築建三;児島雄介;竹林宏記;阪上雅史.;福島久毅;Nguyen KH
• 通讯作者: Nguyen KH

Role of ZNF143 in tumor growth through transcriptional regulation of DNA replication and cell-cycle-associated genes

• DOI: 10.1111/j.1349-7006.2010.01725.x
• 发表时间: 2010-12-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Izumi, Hiroto;Wakasugi, Tetsuro;Kohno, Kimitoshi
• 通讯作者: Kohno, Kimitoshi

Langerhans cell histiocytosis of the petrous bone with sudden sensorineural hearing loss. Case report.

岩骨朗格汉斯细胞组织细胞增多症伴突发感音神经性听力损失。

• 发表时间: 2010
• 期刊: Neurol Med Chir
• 作者: Suzuki H;Wakasugi T;他
• 通讯作者: 他

頭頸部癌におけるシスプラチン感受性/耐性因子としての転写因子ZNF143の機能解析

转录因子ZNF143作为头颈癌顺铂敏感/耐药因子的功能分析

• 发表时间: 2011
• 作者: 若杉哲郎;他
• 通讯作者: 他

Clinical significance of ultrasonographic examination including detection of thyroid gland diseases when surveying cervical lymph nodes in subjects with oral squamous cell carcinoma

口腔鳞癌患者颈淋巴结超声检查包括甲状腺疾病检测的临床意义

• DOI: 10.1016/j.tripleo.2010.01.011
• 发表时间: 2010
• 期刊: Oral Surg Oral Med Oral Pathol Oral Radiol Endod
• 作者: Wakasugi-Sato N;Wakasugi T;Oda M;Yamashita Y;Yoshioka I;Yamamoto N;Habu M;Kodama M;Kokuryo S;Ichimiya H;Miyamoto I;Tanaka T;Kito S;Matsumoto-Takeda S;Ishikawa A;Seta Y;Matsuo K;Takahashi T;Tominaga K;Morimoto Y
• 通讯作者: Morimoto Y