evaluationofeffectivenessoftheobjectiveexaminationforautism indeafchildren
evaluationofeffectivenessoftheobjectiveexaminationforautism indeafchildren
批准号:
22791642
负责人:
YAMAZAKI Hiroshi
金额:
$2.5万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
大约25%的先天性感音神经性听力损失是由先天性巨细胞病毒(CMV)感染引起的,这也影响了更高的大脑功能。我们评估了先天性巨细胞病毒感染的聋儿人工耳蜗植入(CI)的结果,其中一些患有广泛性发育障碍(PDD),包括自闭症。在无PDD的病例中,术后CI辅助的语言发展与术前认知发展显著相关,但在PDD的病例中,其CI辅助的语言发展远低于其认知发展的预期。提示PDD语言发育迟缓的发生机制可能不同于其他高级脑功能障碍包括智力发育迟缓。
英文摘要
Approximately 25% of congenital sensorineural hearing loss is caused by congenital cytomegalovirus (CMV) infection, which also affects higher brain functions. We evaluated cochlear implant (CI) outcomes of deaf children with congenital CMV infection, some of which suffered from pervasive developmental disorders (PDD) including autistic disorder. Incases with out PDD, the postoperative CI- aided language development is significantly associated with their preoperative cognitive development,but incases with PDD, their CI- aided language development was much lower than those expected from their cognitive development. These data suggests that mechanism of language retardation in PDD might be d fferent from those in other higher brain dysfunctions including mental retardation.
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人工内耳埋め込み術を施行したauditory neuropathyの1例
人工耳蜗植入术后听神经病变1例
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Horie Y, Saito W, Kitaichi N, Miura T, Ishida S, Ohno S, 山崎博司]
通讯作者:
山崎博司
当科における優性遺伝形式をとる遺伝性難聴症例の検討
我科显性遗传的遗传性听力损失病例检查
DOI:
--
发表时间:
2011
期刊:
厚生労働科学研究費補助金軟治性疾患克服研究事業優性遺伝形式をとる遺伝性難聴に関する調査研究平成22年度総括・分担研究報告書研究代表者宇佐美真一平成23(2011)年3月
影响因子:
--
作者:
[内藤泰, 山崎博司]
通讯作者:
山崎博司
ステロイド依存性の両側混合性難聴を初発症状としたANCA関連血管炎の3例
以类固醇依赖性双侧混合性听力损失为首发症状的 ANCA 相关性血管炎 3 例
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[山崎博司, 内藤泰, 篠原尚吾, 藤原敬三, 菊地正弘, 十名洋介, 金沢佑治, 栗原理紗]
通讯作者:
栗原理紗
内耳奇形を伴う小児人工内耳症例の術後成績
内耳畸形小儿人工耳蜗植入病例的术后结局
DOI:
--
发表时间:
2012
期刊:
Audiology Japan
影响因子:
--
作者:
[諸頭三郎, 山崎博司, 内藤 泰, 眞鍋朋子, 山本輪子, 藤原敬三, 篠原尚吾]
通讯作者:
篠原尚吾
Inner Ear Disorders Observed in ANCA-associated Vasculitis
ANCA 相关性血管炎中观察到的内耳疾病
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Yamazaki H, Naito Y, Shinohara S, Fujiwara K, Kikuchi M, Kanazawa Y, Kurihara R, Kishimoto I]
通讯作者:
Kishimoto I
共 31 条
Relevance to bioactivation and toxicity of thalidomide, pomalidomide, and lenalidomide by human cytochrome P450 3A enzymes in cultured placental cells and humanized-liver mice
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批准号:17K08425
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2017
-
负责人:YAMAZAKI Hiroshi
-
依托单位:
Mechanisms of resistance to molecularly targeted drugs for oral squamous cell carcinoma and investigation of countermeasures
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批准号:16K11732
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2016
-
负责人:YAMAZAKI Hiroshi
-
依托单位:
Development of Effective Markers for Resistance of Oral Squamous Cell Carcinoma to Molecular-targeting Drugs
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批准号:25463120
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
-
财政年份:2013
-
负责人:YAMAZAKI Hiroshi
-
依托单位:
Thalidomide increases cytochrome P450 activity and drug metabolism in liver through direct activation of nuclear receptor CAR and PXR
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批准号:23590200
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.49万
-
财政年份:2011
-
负责人:YAMAZAKI Hiroshi
-
依托单位:
Role of cancer stem cells related molecules in oral squamous cell carcinoma
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批准号:22592246
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2010
-
负责人:YAMAZAKI Hiroshi
-
依托单位:
Molecular mechanism of chemical-induced toxicity in fetal livers
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批准号:17390034
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.07万
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财政年份:2005
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负责人:YAMAZAKI Hiroshi
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依托单位:
Molecular Mechanisms of Toxic Expression Induced by Endocrine Disruptors via AHR
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批准号:15390040
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.64万
-
财政年份:2003
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负责人:YAMAZAKI Hiroshi
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依托单位:
Study on the separation of rac and meso isomers and the reactivity of group 4 bridged metallocene complexes
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批准号:11640544
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.38万
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财政年份:1999
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负责人:YAMAZAKI Hiroshi
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依托单位:
PREDICTION OF DRUG DISPOSITION BY HUMAN DRUG METABOLIZING ENZYMES
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批准号:11557191
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$3.01万
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财政年份:1999
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负责人:YAMAZAKI Hiroshi
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依托单位:
Creation of Substitution Labile Pyrazolylborate Metal Complexes
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批准号:09640675
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.96万
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财政年份:1997
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负责人:YAMAZAKI Hiroshi
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依托单位:
海外基金