Experimental research of the effect of nerve on negative pressure wound therapy and clinical application

神经对负压伤口治疗效果的实验研究及临床应用

• 批准号: 22791743
• 负责人: FUJIWARA Toshihiro
• 金额: $ 2.58万
• 依托单位: Hyogo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791743/
• 关键词: 創傷治癒; 閉鎖陰圧療法; 線維芽細胞; 神経細胞; 繊維芽細胞

Kinetic change of dermal fibroblasts of rats and differentiated PC12 cells like sympathetic ganglionic neuron was investigated under various types of negative pressure. The results indicated that proliferation and migration potencies of dermal fibroblasts were promoted under intermittent negative pressure more than under atmospheric pressure, and collagen gel including dermal fibroblasts contracted under continuous negative pressure more than under atmospheric pressure. Then, the collagen gel in which dermal fibroblasts and differentiated PC12 cells were co-cultured contracted under intermittent negative pressure more than under atmospheric pressure. The results suggested that intermittent negative pressure effectively promotes wound healing.

研究了大鼠真皮成纤维细胞和交感神经节神经元等分化PC12细胞在不同类型负压下的动力学变化。结果表明，间歇负压比大气压下更能促进真皮成纤维细胞的增殖和迁移能力，连续负压下比大气压下更能促进包括真皮成纤维细胞的胶原凝胶的收缩。然后，共培养真皮成纤维细胞和分化的PC12细胞的胶原凝胶在间歇负压下比在大气压下收缩更多。结果表明间歇负压有效促进伤口愈合。

项目成果

細川亙各創傷被覆材の浸透深度の違いによる抗菌効果の比較検討

Wataru Hosokawa 各种伤口敷料渗透深度差异所致抗菌效果的比较研究

• 发表时间: 2010
• 作者: 藤原敏宏福田健児;西本聡;垣淵正男;久保盾貴
• 通讯作者: 久保盾貴

Comparative study of antibacterial penetrating effects of wound dressings

伤口敷料抗菌渗透作用的比较研究

• DOI: 10.3109/2000656x.2011.644939
• 发表时间: 2012
• 期刊: Journal of Plastic Surgery and Hand Surgery
• 影响因子: 1.2
• 作者: Fujiwara T;Nishimoto S;Ishise H;Kawai K;Fukuda K;Kakibuchi M.;Toshihiro Fujiwara
• 通讯作者: Toshihiro Fujiwara

Comparative study of the antibacterial penetrating effects of wound dressings

伤口敷料抗菌渗透作用的比较研究

• 发表时间: 2012
• 期刊: J Plast Surg Hand Surg
• 作者: Fujiwara T;Nishimoto S;Ishise H;Kawai K;Fukuda K;Kakibuchi M.
• 通讯作者: Kakibuchi M.

各創傷被覆材の浸透深度の違いによる抗菌効果の比較検討

各伤口敷料渗透深度差异的抗菌效果对比研究

• 发表时间: 2010
• 作者: 藤原敏宏福田健児;西本聡;垣淵正男;久保盾貴;藤原敏宏
• 通讯作者: 藤原敏宏

各創傷被覆材の菌保持力の比較検討

各伤口敷料材料细菌截留能力的比较研究

• 发表时间: 2010
• 作者: 藤原敏宏;河合建一郎;福田健児;西本聡;垣淵正男
• 通讯作者: 垣淵正男