Elucidation of association and the mechanism of oral bacteria in the circulatory disease

阐明口腔细菌与循环系统疾病的关联及其机制

• 批准号: 22791814
• 负责人: HIRAISHI Yukihiro
• 金额: $ 2.5万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791814/
• 关键词: 免疫; 感染; 炎症; 口腔細菌; 感染性心内膜炎; 大動脈瘤; 細菌; PCR

We obtained dental plaque specimens from the patient who underwent heart valve replacement or removal of aortic aneurysms in Wakayama Medical University. In addition, we collected aortic valve specimens and aortic aneurysmal wall specimens from the same group of patients. Bacterial DNA was extracted from both cardiovascular tissues and dental plaque in those cases. Then, species-specific real-time polymerase chain reaction assays were used to analyze the occurrences of periodontal bacterial species. A streptococcus mutans was the most frequently detected species in the cardiovascular specimens. However our results showed no association between oral bacterial species and bacteria in cardiovascular diseases.

我们从和歌山医科大学接受心脏瓣膜置换术或主动脉瘤切除术的患者身上获取了牙菌斑标本。此外，我们还采集了同组患者的主动脉瓣标本和主动脉瘤壁标本。在这些病例中，从心血管组织和牙菌斑中提取了细菌 DNA。然后，使用物种特异性实时聚合酶链反应测定来分析牙周细菌物种的出现。变形链球菌是心血管样本中最常检测到的物种。然而，我们的结果显示口腔细菌种类与心血管疾病细菌之间没有关联。

项目成果

循環器疾患における口腔内細菌の関連と機序の解明

阐明口腔细菌与心血管疾病的关系和机制

• 发表时间: 2011
• 作者: 槇野秀一、平石幸裕、和田健;他7名
• 通讯作者: 他7名