Development of adhesive nano-hydroxyapatite-collagen composite

将装载有低剂量BMP-2并置于牙本质芯片上的nHAC膜植入大鼠大腿肌肉中，导致在植入后的早期阶段在牙本质表面上形成长而薄的牙骨质样硬组织，而不增加牙本质吸收。另一方面，经EDC交联并添加纤维蛋白胶的nHAC具有更高的弹性。该材料具有良好的生物相容性和生物降解性。结果表明，nHAC-纤维蛋白复合物与BMP-2在大鼠大腿肌肉中异位成骨，适合作为BMP-2的载体。

Implantation of a nHAC membrane that was loaded with low dose of BMP-2 and placed on dentin chips, into rat thigh muscle, resulted in the formation of a long thin, cementum-like hard tissue on the dentin surface at an early stage after implantation without increasing dentin resorption. On the other hand, the nHAC, cross-linked by EDC and added fibrin glue has more elastic. This new material showed a good biocompatibility and biodegradability in vivo. nHAC-fibrin composite with BMP-2 resulted in ectopic bone formation in rat thigh muscle, and showed to be suitable as the carrier of BMP-2.