Development of adhesive nano-hydroxyapatite-collagen composite

纳米羟基磷灰石-胶原粘合复合材料的研制

• 批准号: 22791917
• 负责人: TENKUMO Taichi
• 金额: $ 2.75万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791917/
• 关键词: 歯周組織; ナノハイドロキシアパタイト; BMP2; 弾性; BMP-2; 再生療法; ナノ; ハイドロキシアパタイト; 接着性

Implantation of a nHAC membrane that was loaded with low dose of BMP-2 and placed on dentin chips, into rat thigh muscle, resulted in the formation of a long thin, cementum-like hard tissue on the dentin surface at an early stage after implantation without increasing dentin resorption. On the other hand, the nHAC, cross-linked by EDC and added fibrin glue has more elastic. This new material showed a good biocompatibility and biodegradability in vivo. nHAC-fibrin composite with BMP-2 resulted in ectopic bone formation in rat thigh muscle, and showed to be suitable as the carrier of BMP-2.

将装载有低剂量BMP-2并置于牙本质芯片上的nHAC膜植入大鼠大腿肌肉中，导致在植入后的早期阶段在牙本质表面上形成长而薄的牙骨质样硬组织，而不增加牙本质吸收。另一方面，经EDC交联并添加纤维蛋白胶的nHAC具有更高的弹性。该材料具有良好的生物相容性和生物降解性。结果表明，nHAC-纤维蛋白复合物与BMP-2在大鼠大腿肌肉中异位成骨，适合作为BMP-2的载体。

项目成果

Effect of nano-hydroxyapatite on bone morphogenetic protein-2-induced hard tissue formation and dentin resorption on a dentin surface

纳米羟基磷灰石对骨形态发生蛋白2诱导的牙本质表面硬组织形成和牙本质吸收的影响

• DOI: 10.1016/j.apsusc.2012.03.103
• 发表时间: 2012
• 期刊: Applied Surface Science
• 影响因子: 6.7
• 作者: Tamagawa H;Tenkumo T;Sugaya T;Kawanami M
• 通讯作者: Kawanami M