An extended biocompatibility of surface modified titanium implant.

二氧化钛表面的光功能化自由基反应与吸附有机杂质和降低钛基生物材料的亲水性有关。在氧化钛表面自发产生的这种活性氧物种(ROS)也可能对生物能力和附着微生物的随时间变化的降解起到重要作用。这项研究测试了在没有光功能化的氧化钛表面上的体外生物能力与时间和抗菌活性的函数关系。机械抛光和热氧化处理的钛表面存放4周后，表面吸附了有机杂质，表面亲水性降低。即使在储存期后，由于表面生成的ROS和亲水性官能团，阳极氧化的钛表面也能够实现超亲水而不吸附有机杂质。成骨细胞在阳极氧化钛表面的成骨基因表达显著高于热氧化钛和抛光钛表面。钛表面在含有氯化物的溶液中进行阳极氧化，由于表面产生了大量的ROS，因此对口腔微生物具有抗菌活性。因此，钛在氯化物溶液中的阳极氧化有可能成为钛基内固定装置的潜在用途。

Photo-functionalized radical reactions on TiO_2 have been correlated with adsorption of organic impurities and decreasing hydrophilicity of titanium-based biomaterials. Such reactive oxygen species(ROS) spontaneously generated on oxidized titanium surfaces may also have important roles against time-dependent degradation of biological ability and adherent microorganisms. This study examined in vitro biological ability as a function of time and antimicrobial activity on oxidized titanium surfaces without photo-functionalization. Mechanically polished titanium and thermally oxidized titanium surfaces that had been stored for 4 wks showed adsorbed organic impurities with decreased surface hydrophilicity. Even after the storage period, anodically oxidized titanium surfaces enabled super-hydrophilicity without adsorption of organic impurities, because of the ROS and the hydrophilic functional groups generated on the surfaces. The osteogenic gene expressions of osteoblasts cultured on anodically oxidized titanium surfaces with or without storage were significantly higher than those on thermally oxidized titanium and polished titanium surfaces. Titanium surfaces anodically oxidized in a solution with chloride achieved antimicrobial activity against an oral microorganism due to the amount of ROS generated on the surface. Thus, titanium anodically oxidized in solution with chloride may have potential use for titanium-based internal fixation devices.