An extended biocompatibility of surface modified titanium implant.

表面改性钛植入物的扩展生物相容性。

• 批准号: 22791939
• 负责人: SHIBATA Yo
• 金额: $ 2.58万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791939/
• 关键词: チタン; インプラント; 陽極酸化; 表面分析; フリーラジカル; 細胞; 表面処理; 活性酸素

Photo-functionalized radical reactions on TiO_2 have been correlated with adsorption of organic impurities and decreasing hydrophilicity of titanium-based biomaterials. Such reactive oxygen species(ROS) spontaneously generated on oxidized titanium surfaces may also have important roles against time-dependent degradation of biological ability and adherent microorganisms. This study examined in vitro biological ability as a function of time and antimicrobial activity on oxidized titanium surfaces without photo-functionalization. Mechanically polished titanium and thermally oxidized titanium surfaces that had been stored for 4 wks showed adsorbed organic impurities with decreased surface hydrophilicity. Even after the storage period, anodically oxidized titanium surfaces enabled super-hydrophilicity without adsorption of organic impurities, because of the ROS and the hydrophilic functional groups generated on the surfaces. The osteogenic gene expressions of osteoblasts cultured on anodically oxidized titanium surfaces with or without storage were significantly higher than those on thermally oxidized titanium and polished titanium surfaces. Titanium surfaces anodically oxidized in a solution with chloride achieved antimicrobial activity against an oral microorganism due to the amount of ROS generated on the surface. Thus, titanium anodically oxidized in solution with chloride may have potential use for titanium-based internal fixation devices.

TiO_2上的光功能化自由基反应与有机杂质的吸附和钛基生物材料亲水性的降低有关。这种活性氧物种（ROS）氧化钛表面上自发产生的也可能有重要的作用，对时间依赖性降解的生物能力和粘附的微生物。本研究检查了未进行光功能化的氧化钛表面的体外生物学能力（随时间变化）和抗微生物活性。机械抛光的钛和热氧化的钛表面，已被储存4周显示吸附的有机杂质与降低的表面亲水性。即使在储存期之后，阳极氧化的钛表面也能够实现超亲水性而不吸附有机杂质，这是因为表面上产生的ROS和亲水性官能团。成骨细胞的成骨基因表达的阳极氧化钛表面有或没有存储显着高于热氧化钛和抛光钛表面。由于表面产生大量的活性氧，钛表面在含有氯化物的溶液中阳极氧化后，可以对口腔微生物产生抗微生物活性。因此，钛在氯化物溶液中阳极氧化可能具有用于钛基内固定器械的潜在用途。

项目成果

The characteristics of in vitro biological activity of titanium surfaces anodically oxidized in chloride solutions.

• DOI: 10.1016/j.biomaterials.2010.07.098
• 发表时间: 2010-11
• 期刊: Biomaterials
• 影响因子: 14
• 作者: Y. Shibata;D. Suzuki;S. Omori;R. Tanaka;A. Murakami;Y. Kataoka;Kazuyoshi Baba;R. Kamijo

Role of Chloride Formed on Anodized Titanium Surfaces Against an Oral Microorganism

• DOI: 10.1177/0885328209349316
• 发表时间: 2010-08-01
• 期刊: JOURNAL OF BIOMATERIALS APPLICATIONS
• 影响因子: 2.9
• 作者: Deng, Jia-Yin;Arimoto, Takafumi;Igarashi, Takeshi
• 通讯作者: Igarashi, Takeshi

チタンインプラントの高機能化を目指した表面改質

旨在提高钛植入物功能的表面改性

• 发表时间: 2010
• 作者: 柴田陽;宮崎隆
• 通讯作者: 宮崎隆

Antimicrobial Activity and Osteoblastic Responses to Anodically Oxidized Titanium Surfaces.

对阳极氧化钛表面的抗菌活性和成骨细胞反应。

• 发表时间: 2011
• 作者: Akiyama T;et al;Tanaka R
• 通讯作者: Tanaka R

Role of chloride formed on anodized titanium surtaces against an oral microorganism

阳极氧化钛表面形成的氯化物对口腔微生物的作用

• 发表时间: 2010
• 期刊: J Biomater Appl
• 影响因子: 2.9
• 作者: Deng JY;Arimoto T;Shibeta Y;Omori S;Miyazaki T;Igarashi T.
• 通讯作者: Igarashi T.