An extended biocompatibility of surface modified titanium implant.

TiO_2上的光官能化自由基反应与有机杂质的吸附和钛基生物材料亲水性的降低有关。这种在氧化钛表面自发产生的活性氧（ROS）也可能对生物能力和附着微生物的时间依赖性降解具有重要作用。本研究考察了体外生物能力作为时间的函数和抗菌活性氧化钛表面没有光功能化。经过机械抛光和热氧化处理4周后，钛表面吸附有机杂质，表面亲水性下降。即使在储存期后，阳极氧化的钛表面仍然具有超亲水性，而不吸附有机杂质，这是因为表面上产生了活性氧和亲水性官能团。氧化钛表面和抛光钛表面培养的成骨细胞成骨基因表达量显著高于氧化钛表面培养的成骨细胞。钛表面在含氯化物的溶液中阳极氧化，由于表面上产生的活性氧量，实现了对口腔微生物的抗菌活性。因此，钛在氯化物溶液中阳极氧化可能具有用于钛基内固定装置的潜在用途。

Photo-functionalized radical reactions on TiO_2 have been correlated with adsorption of organic impurities and decreasing hydrophilicity of titanium-based biomaterials. Such reactive oxygen species(ROS) spontaneously generated on oxidized titanium surfaces may also have important roles against time-dependent degradation of biological ability and adherent microorganisms. This study examined in vitro biological ability as a function of time and antimicrobial activity on oxidized titanium surfaces without photo-functionalization. Mechanically polished titanium and thermally oxidized titanium surfaces that had been stored for 4 wks showed adsorbed organic impurities with decreased surface hydrophilicity. Even after the storage period, anodically oxidized titanium surfaces enabled super-hydrophilicity without adsorption of organic impurities, because of the ROS and the hydrophilic functional groups generated on the surfaces. The osteogenic gene expressions of osteoblasts cultured on anodically oxidized titanium surfaces with or without storage were significantly higher than those on thermally oxidized titanium and polished titanium surfaces. Titanium surfaces anodically oxidized in a solution with chloride achieved antimicrobial activity against an oral microorganism due to the amount of ROS generated on the surface. Thus, titanium anodically oxidized in solution with chloride may have potential use for titanium-based internal fixation devices.