Evaluation of the taste disorder generation mechanism and development of the cure with fluoropyrimidine anticancer drugs.

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Although taste disorders are frequently observed in cancer patients undergoing chemotherapy, generation mechanism is unknown. The aim of the study was to reveal generation mechanism of taste disorders. In S-1 administered rats, no morphologic changes in mucosal epithelia basal cells and taste buds were observed. Immunohistochemical staining for a neuronal marker, PGP 9.5, detected nerve fibers in the epithelium and subepithelium of the taste bud. And degeneration of taste cells in the ganglia was significantly increased. The taste disorders by the anticancer drug administration do not generate from the impairment of mucosal epithelia and taste bud, but possibility from neuropathy of the gustatory nerve.