An association between MICAgene and an increased susceptibility to oral squamous cell carcinoma

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Recently, a new polymorphic gene family called the major histocompatibility complex class I chain-related gene A (MICA) was discovered about 40 kb centromeric to HLA-B gene. The MICA protein, expressed on epithelial cells and many kinds of tumor cells, serves to regulate immune function. The MICA protein is thought to activate immune function on mucosal tissue by binding to NKG2D which is expressed on most natural killer cells, CD8 positive T cells, and gamma delta T cells. An association between MICA gene polymorphisms and the development of oral squamous cell carcinoma (OSCC) has also been reported.This study was designed to test this association in Japanese patients with OSCC.The (GCT)n polymorphisms of the MICA gene was investigated in OSCC patients and normal controls using polymerase chain reaction amplification and denaturing polyacrylamide gel electrophoresis.Five alleles, namely A4, A5, A6, A9, and A5.1, were found in both groups. The MICA-A5.1 allele was significantly higher in patients with OSCC when compared with normal controls These results suggest that the MICAA5.1 allele may be associated with an increased susceptibility