Regeneration of trigeminal nerve ending mechanoreceptor function.-As an indication of ideal orthodontic treatment intervention time.

三叉神经末梢机械感受器功能的再生。-作为理想正畸治疗干预时间的指示。

• 批准号: 22792042
• 负责人: ISHIDA Takayoshi
• 金额: $ 2.58万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22792042/
• 关键词: 顎関節; 機械受容器; 三叉神経節; 電気生理学; ラット; 液状飼料; 顎関節機械受容器

Previous studies have reported that the maturation of temporomandibular joint(TMJ) mechanoreceptors was promoted in the early masticatory stage and TMJ mechanoreceptors could not sustain their function when masticatory loading was decreased. The purpose of the present study was to investigate whether a resumption of proper TMJ loading during the early growth period could lead to the restoration of TMJ mechanoreceptor function. Ninety-nine 2-week-old male Wistar rats were divided into two groups and feeding was started with either pellets[ control group(n=33)] or liquid diet[ experimental group(n=66)]. The experimental group was further divided into changing-diet(n=33) and liquid-diet(n=33) groups ; the former was fed pellets instead of liquid diet from 5 weeks. TMJ mechanoreceptor activities were recorded from the trigeminal ganglion at 5, 7 and 9 weeks. The firing threshold and maximum instantaneous firing frequency were measured in each group in comparison with the control group. The firing properties of single TMJ units in each experimental subgroup were compared to those in the control group. In the changing-diet group, the firing properties of TMJ units were recovered at 7 weeks. In conclusion, proper TMJ loading during the early growth period can lead to the restoration of TMJ mechanoreceptor function.

以往的研究表明，颞下颌关节（TMJ）机械感受器在咀嚼运动的早期即已成熟，当咀嚼负荷降低时，TMJ机械感受器的功能不能维持。本研究的目的是调查是否恢复适当的颞下颌关节负荷在生长早期可能会导致颞下颌关节机械感受器功能的恢复。将99只2周龄雄性Wistar大鼠分为两组，开始喂食颗粒饲料[对照组（n=33）]或流质饲料[实验组（n=66）]。实验组又分为换料组和流食组，换料组从第5周开始用颗粒饲料代替流食。在第5、7和9周记录三叉神经节的TMJ机械感受器活动。测量各组大鼠的放电阈值和最大瞬时放电频率，并与对照组进行比较。将每个实验亚组中单个TMJ单位的放电特性与对照组中的放电特性进行比较。在饮食改变组中，颞下颌关节单位的放电特性在7周时得到恢复。因此，在生长早期给予适当的颞下颌关节负荷，可促进颞下颌关节机械感受器功能的恢复。

项目成果

低重力環境と前庭動眼反射の応答

低重力环境与前庭眼反射反应

• 发表时间: 2009
• 作者: Ishida T.;Zeredo J L.;Yabushita T.;Seki S.;Fusejima Y.;Fukushima G.;Toda K.;Kumei Y.;野村泰之,池田篤生,増田毅,戸井輝夫,平井良治,肥田和恵,鴫原俊太郎,池田稔,粂井康宏,薮下忠親,石田宝義,ゼレドジョージ
• 通讯作者: 野村泰之,池田篤生,増田毅,戸井輝夫,平井良治,肥田和恵,鴫原俊太郎,池田稔,粂井康宏,薮下忠親,石田宝義,ゼレドジョージ

Increased occlusal vertical dimension induces cortical plasticity in ratface primary motor cortex

咬合垂直尺寸的增加诱导鼠面初级运动皮层的皮质可塑性

• 发表时间: 2011
• 期刊: Behavioural Brain Research
• 影响因子: 2.7
• 作者: Kato C;Fujita K;Naito S;Shibata M;Ishida T;Kokai S;Yabushita T;Ono T
• 通讯作者: Ono T

Evidence of functional recovery in nerve system after early correction of masticatory environment during growth period.:-Focus on activity of Temporomandibular joint mechanoreceptors in rats

生长期咀嚼环境早期矫正后神经系统功能恢复的证据：-关注大鼠颞下颌关节机械感受器的活动

• 发表时间: 2010
• 作者: Ishida T;Yabushita T;Soma K
• 通讯作者: Soma K

成長発育期における咀嚼環境の改善は咀嚼神経システムの機能を回復する-顎関節機械受容器の応答特性に着目して-

改善生长发育过程中的咀嚼环境，恢复咀嚼神经系统的功能 -关注颞下颌关节机械感受器的反应特征-

• 发表时间: 2010
• 作者: 石田宝義;藪下忠親;小野卓史
• 通讯作者: 小野卓史

咬合高径増加がラット大脳皮質一次運動野顎顔面領域における機能局在に与える影響

咬合高度增加对大鼠大脑皮层初级运动皮层颌面部功能定位的影响

• 发表时间: 2011
• 作者: 加藤千帆;藤田紘一;藪下忠親;内藤聡美;柴田真衣;石田宝義;小海暁;小野卓史
• 通讯作者: 小野卓史