The building of technical bases for real time imaging of bone remodeling caused by orthodontic force

本研究的目的是通过研究正畸力、骨密度、骨改建和血管生成之间的关系，为建立合适的正畸治疗评价方法提供技术基础。我们建立了利用荧光探针监测小鼠皮下肿瘤血管生成的体内成像技术。我们开发了实验技术来监测当施加正畸力时牙周组织的变化。用小鼠骨质疏松症模型进行的实验表明，骨密度和正畸力对牙周组织的骨改建和血管生成有一定的影响。

The aim of this study is the building of technical bases for appropriate methods of evaluation for orthodontic treatments by means of the study of the relationships among orthodontic force, bone density, bone remodeling and angiogenesis. We established in vivo imaging technique for monitoring of angiogenesis in mouse subcutaneous tumor by using fluorescent probes. We developed experimental technique to monitor the change of periodontium when the orthodontic force was applied. The experiments using mouse model of osteoporosis suggested the implication of bone density and orthodontic force to bone remodeling and angiogenesis in periodontium.