The molecular mechanism of soft palate development

为了解软腭发育的机制，本实验进行了研究。我们发现在软腭发育过程中，Periostin有一种独特的表达模式，这与腭腱膜中的I型胶原(Col I)密切相关。此外，器官培养分析表明，外源性转化生长因子-β诱导了Periostin和Col I的表达。在软腭发育的功能结构形成过程中，转化生长因子-b信号似乎是Col I和Periostin表达的中介之一。

The experiment was performed for understanding of the mechanism of soft palate development. We demonstrated a unique pattern of periostin expression during soft palate development, which was closely related to that of collagen type I(Col I) in palatine aponeurosis. Furthermore, organ culture analysis showed that exogenous transforming growth factor-β(TGF-b) induced the expression of both periostin and Col I. TGF-b signaling appears to be one of the mediators of Col I and periostin expression in the formation of functional structures during soft palate development.