Development of highly functional asymmetric catalysis and reagents by using coordinative group

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In order to develop the synthesis of chiral compounds, we designed novel organocatalysts having a coordinative heteroaryl group in their structures. Although enantioselective aldol reaction to ketone is generally difficult, the reaction using our novel organocatalysts afforded good results. Especially, biologically active flustraminol and AG-041R derivatives can be prepared by using the organocatalysts. Furthermore, organocatalyst could be readily reusable without significant loss of catalytic activity or enantioselectivity.