Biochemical screen and functional analysis of a protein complexrequired for selective degradation of mitochondria

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Selective degradation of damaged or surplus mitochondria is important for cellular homeostasis. Recently, it has been proposed that degradation of mitochondria, termed mitophagy, is critical for mitochondrial quality control system. However, the molecular mechanisms remain largely unkown. We identified the specific mitochondrial receptor Atg32 that is essential for the mitophagy using budding yeast. In this study, we performed the biochemical screening and identified novel factors interacting with Atg32.