Mechanism of centromer i c chromatin formation through the regulation of hi stone acetylation
Mechanism of centromer i c chromatin formation through the regulation of hi stone acetylation
批准号:
22770181
负责人:
HAYASHI Takeshi
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
着丝粒是有丝分裂过程中染色体正确分离所必需的染色体区域。在这项研究中,我们确定了Mis16复合物的分子组织,这是至关重要的着丝粒染色质的形成。我们确定了组蛋白乙酰转移酶和新的着丝粒蛋白质Mis16相互作用的蛋白质。我们推测Mis16调控组蛋白乙酰化对着丝粒染色质的形成至关重要。
英文摘要
Centromeres are chromosomal regions essential for proper chromosome segregation during mitosis. In this research, we determined molecular organization of Mis16 complex which is essential for centromeric chromatin formation. We identified a histone acetyltransferase and novel centromere proteins as Mis16-interacting proteins. We speculate that the regulation of histone acetylation through Mis16 is vital for centromeric chromatin formation.
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专著(0)
科研奖励(0)
会议论文
CENP-A局在化に必須なMis18複合体の新規構成因子の同定
鉴定出 CENP-A 定位所必需的 Mis18 复合物的新成分
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[林武志, 長尾恒治, 國分綾, 江部正弘, 藤田陽太, 柳田充弘]
通讯作者:
柳田充弘
Mis17 Is a Regulatory Module of the Mis6-Mal2-Sim4 Centromere Complex That Is Required for the Recruitment of CenH3/CENP-A in Fission Yeast
Mis17 是 Mis6-Mal2-Sim4 着丝粒复合物的调节模块,是裂殖酵母中招募 CenH3/CENP-A 所必需的
DOI:
--
发表时间:
2011
期刊:
PLoS One
影响因子:
3.7
作者:
[Y. Shiroiwa, T. Hayashi, Y. Fujita, A. Villar-Briones, N. Ikai, K. Takeda, M. Ebe and M. Yanagida]
通讯作者:
M. Ebe and M. Yanagida
Hydrological study on groundwater environment in a coastal area
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批准号:19710005
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.31万
-
财政年份:2007
-
负责人:HAYASHI Takeshi
-
依托单位:
Modernity in the traditional technologies.
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批准号:02044132
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$4.99万
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财政年份:1990
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负责人:HAYASHI Takeshi
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依托单位:
海外基金