Analysis of histone deacetylase function in yeast meiosis and sporulation

为了了解组蛋白脱乙酰酶(HDAC)在减数分裂中的作用，本研究分析了Rpd3/HDAC的生物学和分子功能，它是芽期酵母减数分裂和产孢子过程中必不可少的。结果表明，Rpd3调节核小体在中期减数分裂基因启动子的位置，需要及时去除转录抑制因子Sum1来诱导其转录。除了这一功能，这项研究的数据表明，Rpd3在减数分裂和孢子形成过程中可能在多个步骤中发挥作用。

To understand the role of histone deacetylase (HDAC) during meiosis, this study analyzed the biological and molecular function of Rpd3/HDAC, which is essential for progression of meiosis and sporulation in budding yeast. The results have revealed that Rpd3 regulates the nucleosome positioning at the promoter of the middle meiotic genes and it is required for the timely removal of the transcriptional repressor Sum1 to induce their transcription. In addition to this function, the data from this study suggest the possibility that Rpd3 functions at multiple steps during meiosis and sporulation.