Peroxidation of skin lipids : a role of nutraceutical foods as the inhibitor

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When skin is exposed to air environment including sunlight, peroxidation of the skin surface lipids can occur. Indeed, we have previously found that peroxidation of squalene occurs in human skin surface lipids. In this study, we confirmed the findings (skin squalene peroxidation), and found that squalene hydroperoxide induces skin inflammatory responses. As a preventive strategy, the inflammation could be reduced via the use of rice tocotrienol. Squalene hydroperoxide (a peroxidation product of skin surface lipids)would therefore be considered a potential therapeutic target for skin inflammatory disorders, and tocotrienol has potential use as a protective agent against skin diseases.