Effectof CLA on crosstalk between Myostatin and Leptin in muscle tissues on complete grass-fed beef production system

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To further understand the complete grass-fed beef production system, we investigated the effect of CLA on crosstalk between Myostatin and Leptin in muscle tissue. We analyzed body weight, rate of muscle fiber, mRNA expression of muscle specific gene, and morphological and physiological analysis in Japanese shorthorn(N) and F2((N×salers(S))×N : NSN). We found that fast skeletal muscle fiber type switched to slow skeletal muscle fiber type, and slow skeletal muscle fiber type hypertrophied in theM. serratus ventralis. Furthermore, the concentration of serum NEFA increased during grazing period, and hypertrophy of muscle tissue was not involved with differentiation of myotube. We showed that crosstalk between Myostatin and Leptin, and theeffect of CLA on myotube formation. These finding suggested that an unknown factor in cattle serum may induce differentiation of myotube during grazing period.