Role of nucleocapsid protein of Mononegaviruses in evasion of innate immunity

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Rabies virus, by a function of its nucleocapcid(N) protein, evades activation of the cellular factor RIG-I, which recognizes viral RNA and plays important role in induction of type I interferon. The aim of this study was to elucidate the molecular mechanism underlying this phenomenon. We found that amino acids at positions 273 and 394 in N protein are important for evasion of RIG-I activation. Also, we determined molecular structure of defective interfering(DI) RNAs, which is a possible target for RIG-I, and established molecular basis to quantify DI RNAs.