MicroRNA expression in the canine tumor

MicroRNA在犬肿瘤中的表达

• 批准号: 22780283
• 负责人: MIURA Naoki
• 金额: $ 2.58万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22780283/
• 关键词: イヌ; microRNA; 腫瘍; 疾患マーカー; 獣医学; 臨床; micro RNA; 腫瘍マーカー; 癌

A few novel microRNAs, which was up-or down-regulated in either mammary gland tumor or melanoma, were identified by the canine micro RNA microarray. The differential expression of these microRNAs was confirmed by quantitative RT-PCR. We also found that miR-21 and miR-92a had been significantly higher existing in the plasma from dog with mammary gland tumor compared to clinically healthy dog.

通过犬微小RNA微阵列鉴定出一些在乳腺肿瘤或黑色素瘤中上调或下调的新型微小RNA。通过定量 RT-PCR 证实了这些 microRNA 的差异表达。我们还发现，与临床健康狗相比，患有乳腺肿瘤的狗血浆中存在的 miR-21 和 miR-92a 显着较高。

项目成果

犬の口腔内悪性黒色腫の発現microRNAの網羅的解析

犬口腔恶性黑色素瘤中microRNA表达的综合分析

• 发表时间: 2012
• 作者: 前村忠;三浦直樹;伊藤敏生;岩永朋子;川口博明;三好宣彰;桃井康行
• 通讯作者: 桃井康行