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Molecular mechanism of meiotic arrest through Mos-MAPK pathway in mouse oocytes

Molecular mechanism of meiotic arrest through Mos-MAPK pathway in mouse oocytes
Mos-MAPK通路抑制小鼠卵母细胞减数分裂的分子机制
批准号:
22780299
负责人:
KANEMORI Yoshinori
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
Ovulated oocytes are arrested at the metaphase of second meiotic division (metaphase-II). In this study, we showed possible role of mitogen-and stress-activated kinase 1, MSK1 known as a downstream kinase of the Mos-MAPK pathway, in the mouse oocytes. MSK1 exhibited the ability to phosphorylate four Ser/Thr residues of meiotic cell-cycle regulator EMI2. The phosphorylation was required for up-regulation of the EMI2 activity in the oocytes. These results suggested that mouse MSK1 may play a key role in the metaphase-II arrest through phosphorylation of EMI2.
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(These authors contributed equally) Possible involvement of mitogen-and stress-activated protein kinase 1, MSK1
(这些作者的贡献相同)有丝分裂原和应激激活蛋白激酶 1、MSK1 可能参与其中
DOI: --
发表时间: 2011
期刊: in metaphase-II arrest through phosphorylation of EMI2 in mouse oocytes. Developmental Biology
影响因子: --
作者: [Miyagaki, Y., Kanemori, Y. and Baba, T]
通讯作者: T
DOI: 10.1016/j.ydbio.2011.08.021
发表时间: 2011-11
期刊: Developmental biology
影响因子: 2.7
作者: [Yu Miyagaki;Yoshinori Kanemori;T. Baba]
通讯作者: Yu Miyagaki;Yoshinori Kanemori;T. Baba
DOI: 10.1016/j.devcel.2011.06.029
发表时间: 2011-09-13
期刊: DEVELOPMENTAL CELL
影响因子: 11.8
作者: [Isoda, Michitaka, Sako, Kosuke, Sagata, Noriyuki]
通讯作者: Sagata, Noriyuki
Direct phosphorylation of EMI2 by MSK1 in the Mos-MAPK pathway during oocyte maturation
卵母细胞成熟过程中 Mos-MAPK 通路中 MSK1 直接磷酸化 EMI2
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Miyagaki, Y., Kanemori, Y. and Baba, T]
通讯作者: T
10
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    • 批准号:
      26450499
    • 项目类别:
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    • 资助金额:
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    • 财政年份:
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    • 项目类别:
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    • 财政年份:
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