Molecular mechanism of meiotic arrest through Mos-MAPK pathway in mouse oocytes
Molecular mechanism of meiotic arrest through Mos-MAPK pathway in mouse oocytes
批准号:
22780299
负责人:
KANEMORI Yoshinori
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
Ovulated oocytes are arrested at the metaphase of second meiotic division (metaphase-II). In this study, we showed possible role of mitogen-and stress-activated kinase 1, MSK1 known as a downstream kinase of the Mos-MAPK pathway, in the mouse oocytes. MSK1 exhibited the ability to phosphorylate four Ser/Thr residues of meiotic cell-cycle regulator EMI2. The phosphorylation was required for up-regulation of the EMI2 activity in the oocytes. These results suggested that mouse MSK1 may play a key role in the metaphase-II arrest through phosphorylation of EMI2.
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(These authors contributed equally) Possible involvement of mitogen-and stress-activated protein kinase 1, MSK1
(这些作者的贡献相同)有丝分裂原和应激激活蛋白激酶 1、MSK1 可能参与其中
DOI:
--
发表时间:
2011
期刊:
in metaphase-II arrest through phosphorylation of EMI2 in mouse oocytes. Developmental Biology
影响因子:
--
作者:
[Miyagaki, Y., Kanemori, Y. and Baba, T]
通讯作者:
T
DOI:
10.1016/j.ydbio.2011.08.021
发表时间:
2011-11
期刊:
Developmental biology
影响因子:
2.7
作者:
[Yu Miyagaki;Yoshinori Kanemori;T. Baba]
通讯作者:
Yu Miyagaki;Yoshinori Kanemori;T. Baba
DOI:
10.1016/j.devcel.2011.06.029
发表时间:
2011-09-13
期刊:
DEVELOPMENTAL CELL
影响因子:
11.8
作者:
[Isoda, Michitaka, Sako, Kosuke, Sagata, Noriyuki]
通讯作者:
Sagata, Noriyuki
Direct phosphorylation of EMI2 by MSK1 in the Mos-MAPK pathway during oocyte maturation
卵母细胞成熟过程中 Mos-MAPK 通路中 MSK1 直接磷酸化 EMI2
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Miyagaki, Y., Kanemori, Y. and Baba, T]
通讯作者:
T
Possible involvement of mitogen-and stress-activated protein kinase 1, MSK1
丝裂原和应激激活蛋白激酶 1 (MSK1) 可能参与其中
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Miyagaki, Y., Kanemori, Y. and Baba, T]
通讯作者:
T
共 10 条
Dynamics of actin cytoskeleton during mammalian spermatogenesis
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批准号:26450499
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.33万
-
财政年份:2014
-
负责人:KANEMORI Yoshinori
-
依托单位:
Elucidation of the molecular network controlling sperm acrosome formation in mammals
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批准号:24780327
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.91万
-
财政年份:2012
-
负责人:KANEMORI Yoshinori
-
依托单位:
海外基金