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The role of stress proteins in gastrointestinal and respiratory diseases

The role of stress proteins in gastrointestinal and respiratory diseases
应激蛋白在胃肠道和呼吸系统疾病中的作用
批准号:
22790072
负责人:
TANAKA Kenichiro
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
Idiopathic pulmonary fibrosis(IPF) is thought to involve inflammatory infiltration of leukocytes, lung injury induced by reactive oxygen species(ROS), in particular superoxide anion, and fibrosis(collagen deposition). Intravenous administration of PC-SOD suppressed the bleomycin-induced increase in the number of leukocytes in bronchoalveolar lavage fluid. Bleomycin-induced collagen deposition and increased hydroxyproline levels in the lung were also suppressed in animals treated with PC-SOD, suggesting that PC-SOD suppresses bleomycin-induced pulmonary fibrosis.
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DOI: 10.1124/jpet.111.179051
发表时间: 2011-09-01
期刊: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
影响因子: 3.5
作者: [Tanaka, Ken-Ichiro, Tanaka, Yuta, Mizushima, Tohru]
通讯作者: Mizushima, Tohru
Protective effect of β-(1,3 → 1,6)-d-glucan against irritant-induced gastric lesions
β-(1,3 → 1,6)-d-葡聚糖对刺激性胃损伤的保护作用
DOI: --
发表时间: 2011
期刊: British Journal of Nutrition
影响因子: 3.6
作者: [Ken, Yuta Tanaka, Toshio Suzuki, T. Mizushima]
通讯作者: T. Mizushima
Therapeutic effect of lecithinized superoxide dismutase (PC-SOD) on bleomycin-induced pulmonary fibrosis.
卵磷脂化超氧化物歧化酶(PC-SOD)对博来霉素诱导的肺纤维化的治疗作用。
DOI: --
发表时间: 2010
期刊: Am J Physiol Lung Cell Mol Physiol.
影响因子: --
作者: [Tanaka KI., Ishihara T., Azuma A., Kudoh S., Ebina M., Nukiwa T., Sugiyama Y., Tasaka Y., Namba T., Ishihara T., Sato K., Mizushima Y., Mizushima T.]
通讯作者: Mizushima T.
DOI: 10.1016/j.bcp.2011.06.030
发表时间: 2011-10-01
期刊: BIOCHEMICAL PHARMACOLOGY
影响因子: 5.8
作者: [Ishihara, Tomoaki, Suemasu, Shintaro, Mizushima, Tohru]
通讯作者: Mizushima, Tohru
6
    Psychological research on the developmental metamorphosis of leader identity
    • 批准号:
      24653167
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $1.0万
    • 财政年份:
      2012
    • 负责人:
      TANAKA Kenichiro
    • 依托单位:
    Regulation of inflammation by stress proteins
    Study of accurate numerical methods and verified computation relating to stochastic differential equations
    Elucidation of reaction mechanism of site-specific chemical bond scission on self-assembled monolayers as a reaction platform
    • 批准号:
      21350014
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.31万
    • 财政年份:
      2009
    • 负责人:
      TANAKA Kenichiro
    • 依托单位:
    海外基金